Results 71 to 80 of about 159,014 (249)

Human parainfluenza virus evolution during lung infection of immunocompromised humans promotes viral persistence.

Journal of Clinical Investigation, 2021
The capacity of respiratory viruses to undergo evolution within the respiratory tract raises the possibility of evolution under the selective pressure of the host environment or drug treatment.
A. Greninger, K. Rybkina, Michelle J. Lin, Jennifer Drew-Bear, T. Marcink, Ryan C. Shean, Negar Makhsous, M. Boeckh, Olivia E Harder, F. Bovier, S. Burstein, S. Niewiesk, B. Rima, M. Porotto, A. Moscona   +14 more
semanticscholar   +1 more source

A large‐scale single‐cell transcriptomic atlas indicates the immune panorama of influenza A infection

iMeta, EarlyView.
The study presents a large‐scale single‐cell transcriptomic atlas profiling over 612,010 peripheral immune cells from 97 individuals to decode the heterogeneity of influenza infection. These findings indicate a fundamental immune dichotomy determining clinical trajectories: a protective, monocyte‐centric antiviral state in mild disease versus a ...
Yi Wang, Shuzi Liu, Laurence Don Wai Luu, Yongzhi Zhai, Chenliang Zhu, Zhaomin Feng, Yao Tan, Linglong Wan, Jie Wang, Juan Zhou, Jing Wang, Lixin Xie, Quanyi Wang, Fei Xie   +13 more
wiley   +1 more source

Characterization of human parainfluenza virus type 3 persistent infection in cell culture [PDF]

Journal of Virology, 1990
Three cell lines persistently infected with human parainfluenza virus type 3 were characterized on a molecular level in this study. All six structural protein genes were transcribed into monocistronic RNAs in the persistently infected cells. In both acutely and persistently infected cells, polycistronic transcripts were abundant, although the ratio of ...
A, Moscona, M S, Galinski
openaire   +2 more sources

Human parainfluenza 3 and respiratory syncytial viruses detected in pangolins

Emerging Microbes and Infections, 2022
Pangolins have gained increasing global attention owing to their public health significance as potential zoonotic hosts since the identification of SARS-CoV-2-related viruses in them. Moreover, these animals could carry other respiratory viruses. In this
Tengcheng Que, Jing Li, Yugan He, Panyu Chen, Wei Lin, Meihong He, Lei Yu, Aiqiong Wu, Luohao Tan, Yingjiao Li, Yanling Hu, Yigang Tong   +11 more
doaj   +1 more source

The Use of Aerosolized Ribavirin in Respiratory Syncytial Virus Lower Respiratory Tract Infections in Adult Immunocompromised Patients: A Systematic Review [PDF]

, 2019
Introduction: Respiratory syncytial virus (RSV)–associated lower respiratory tract infection (LRTI) is a concern in immunocompromised patients. Aerosolized ribavirin (RBV AER) is used for treatment of RSV LRTI; however, adverse events and rising drug ...
Avery, Lisa M., Hoffmann, Charles, Whalen, Karen M.   +2 more
core   +2 more sources

Evidence‐based guideline for clinical practice in the diagnosis, treatment, management, and prevention of recurrent wheezing in infants and toddlers in China

Pediatric Investigation, EarlyView.
ABSTRACT Wheezing is a common respiratory symptom in infants and toddlers, and recurrent wheezing is a significant respiratory disorder affecting this age group. Given the multifactorial etiology of recurrent wheezing, clinical practice lacks standardized diagnostic and therapeutic protocols. Recent years have witnessed substantial progress in clinical
Committee of Pediatrics, China Medical Education Association, Cooperative Group of Asthma, the Subspecialty Group of Respiratory, the Society of Pediatrics, Chinese Medical Association, Pediatric Respiratory Work Committee, Society of Pulmonologists, Chinese Medical Doctor Association, Committee of Pediatrics, Chinese Research Hospital Association, Pediatric Professional Committee of the Chinese Non‐public Medical Institutions Association, Professional Committee of Children's Health and Pharmaceutical Research, China Association of Traditional Chinese Medicine, Children's Safe Medication Branch of China News of Drug Information Association, Pediatric Expert Committee of China Primary Health Care Foundation, China International Medical Foundation   +16 more
wiley   +1 more source

Antigenic variation of human and bovine parainfluenza virus type 3 strains

Journal of General Virology, 1990
Three human and six bovine parainfluenza virus type 3 (PIV3) strains were examined by the use of 60 monoclonal antibodies (MAbs). Fifty-three MAbs to the human C243 strain were directed against six, four, nine and seven epitopes of the haemagglutinin-neuraminidase (HN), fusion (F), nucleocapsid (N) and matrix proteins, respectively.
E, Klippmark, R, Rydbeck, H, Shibuta, E, Norrby   +3 more
openaire   +2 more sources

Protective Antibodies Against Human Parainfluenza Virus Type 3 (HPIV3) Infection [PDF]

, 2020
ABSTRACTHuman parainfluenza virus type III (HPIV3) is a common respiratory pathogen that afflicts children and can be fatal in vulnerable populations, including the immunocompromised. Unfortunately, an effective vaccine or therapeutic is not currently available, resulting in tens of thousands of hospitalizations per year.
Jim Boonyaratanakornkit, Suruchi Singh, Connor Weidle, Justas Rodarte, Ramasamy Bakthavatsalam, Jonathan Perkins, Guillaume B.E. Stewart-Jones, Peter D. Kwong, Andrew T. McGuire, Marie Pancera, Justin J. Taylor   +10 more
openaire   +1 more source

Respiratory viral infections in bone marrow transplant patients: insights from a tertiary care hospital in Rawalpindi, Pakistan

Journal of the Pakistan Medical Association
Objective: To determine the incidence of respiratory viral infections in bone marrow transplant patients. Method: The prospective, descriptive, cross-sectional study was conducted at a tertiary care hospital in Rawalpindi, Pakistan, from September ...
Noman Shakoor, Saifullah Khan Niazi, Eijaz Ghani, Raheel Iftikhar, Ali Rathore, Misbah Noor   +5 more
doaj   +1 more source

Evaluating a parainfluenza virus 5-based vaccine in a host with pre-existing immunity against parainfluenza virus 5. [PDF]

PLoS ONE, 2012
Parainfluenza virus 5 (PIV5), formerly known as simian virus 5 (SV5), is a paramyxovirus often referred to as canine parainfluenza virus (CPI) in the veterinary field. PIV5 is thought to be a contributing factor to kennel cough.
Zhenhai Chen, Pei Xu, Gregory W Salyards, Stephen B Harvey, Balazs Rada, Zhen F Fu, Biao He   +6 more
doaj   +1 more source