Identification of β4GALNT2 as an anti-hPIV3 factor through genome-wide CRISPR/Cas9 library screening [PDF]
Emerging Microbes and InfectionsHuman respirovirus 3 (also known as human parainfluenza virus 3; hPIV3) is a major cause of severe acute respiratory infections in vulnerable populations.
Xuesheng Wu +2 more
exaly +4 more sources
Peptides targeting RAB11A–FIP2 complex inhibit HPIV3, RSV, and IAV replication as broad-spectrum antivirals [PDF]
Cell and BioscienceBackground The cytoskeletal framework plays a critical role in the early stages of human parainfluenza virus type 3 (HPIV3) replication, including viral mRNA synthesis and translation.
Yali Qin, Chen Mingzhou
exaly +3 more sources
Intranasal bovine/human parainfluenza virus 3 vaccine candidates expressing human metapneumovirus wild-type or pre-fusion F protein elicit protective immunity against human metapneumovirus in hamsters [PDF]
Journal of VirologyHuman metapneumovirus (HMPV) and human parainfluenza virus 3 (HPIV3) are among the leading causes of severe pediatric respiratory illness worldwide, and there are no licensed vaccines.
Sirle Saul +9 more
doaj +2 more sources
Genetic Analysis of HPIV3 That Emerged during the SARS-CoV-2 Pandemic in Gwangju, South Korea
Viruses, 2022 Community mitigation measures taken owing to the COVID-19 pandemic have caused a decrease in the number of respiratory viruses, including the human parainfluenza virus type 3 (HPIV3), and a delay in their occurrence.
Sun-Hee Kim +2 more
exaly +3 more sources
Environmental lag effects and clinical characteristics of pediatric human parainfluenza virus type 3 infections [PDF]
Scientific ReportsHuman parainfluenza virus type 3 (HPIV3) is a major cause of severe pediatric respiratory infections in infants, but its association with meteorological factors is not fully understood.
Dan Hong +7 more
doaj +2 more sources
Genetic Diversity and Molecular Analysis of Human Parainfluenza Virus Type 3 in Saint Petersburg (Russia) in 2017–2023: Emergence of a New Phylogenetic Cluster [PDF]
VirusesHuman parainfluenza viruses 3 (hPIV3) are important pathogens, responsible for acute respiratory tract diseases, especially in young children. Information on hPIV3 circulation and their diversity pattern in Russia is limited. The aim of this study was to
Oula Mansour +6 more
doaj +2 more sources
Biomolecules, 2021 The human parainfluenza virus 3 (HPIV3) poses a risk for pneumonia development in young children and immunocompromised patients. To investigate mechanisms of HPIV3 pathogenesis, we characterized the association state and host protein interactions of ...
Joaquin Rodríguez Galvan +2 more
exaly +3 more sources
Human parainfluenza virus 3 fusion protein cleavage: a key determinant of infection and spread [PDF]
Journal of VirologyHuman parainfluenza virus 3 (HPIV3) entry into target cells depends on a viral fusion complex composed of hemagglutinin-neuraminidase (HN) and fusion protein (F).
Kyle Stearns +7 more
doaj +2 more sources
A fusion protein’s weak link: functional constraints revealed by inhibitory peptide interaction with the parainfluenza fusion protein [PDF]
mBioHuman parainfluenza viruses (HPIVs) cause significant respiratory illnesses including croup and pneumonia. HPIV infection begins with fusion of viral and host cell membranes, driven by the coordinated actions of the attachment (HN) and fusion (F ...
Maximilian Crosby +11 more
doaj +2 more sources
Human parainfluenza virus 3 field strains undergo extracellular fusion protein cleavage to activate entry [PDF]
mBioHuman parainfluenza virus 3 (HPIV3) infection is driven by the coordinated action of viral surface glycoproteins hemagglutinin-neuraminidase (HN) and fusion protein (F).
Kyle Stearns +8 more
doaj +2 more sources