Viruses, 2018 Human parainfluenza virus type 3 is one of the main causes of lower respiratory illness in newborns and infants. The role of the matrix protein (M) in viral budding is extensively studied, but the effect of M on viral replication remains to be determined.
Shengwei Zhang +2 more
exaly +5 more sources
Potent HPIV3-neutralizing IGHV5-51 Antibodies Identified from Multiple Individuals Show L Chain and CDRH3 Promiscuity [PDF]
Journal of ImmunologyAbstract Human parainfluenza virus 3 (HPIV3) is a widespread pathogen causing severe and lethal respiratory illness in at-risk populations. Effective countermeasures are in various stages of development; however, licensed therapeutic and prophylactic options are not available.
Alexandra A Abu-Shmais +2 more
exaly +4 more sources
Respiratory virus-induced bacterial dysregulation in pediatric airway tissue and the dual actions of Echinacea in reducing complications [PDF]
Frontiers in PharmacologyIntroductionRespiratory tract infections (RTIs) contribute to pediatric morbidity and are often complicated by viral-bacterial superinfections, which exacerbate disease severity and increase antibiotic use.
Selvarani Vimalanathan +7 more
doaj +2 more sources
Genetic characteristics of human parainfluenza viruses 1–4 associated with acute lower respiratory tract infection in Chinese children, during 2015–2021 [PDF]
Microbiology SpectrumHuman parainfluenza viruses (HPIVs) are a significant cause of acute lower respiratory tract infections (ALRTIs) among young children and elderly individuals worldwide.
Yun Zhu +11 more
doaj +2 more sources
How a paramyxovirus fusion/entry complex adapts to escape a neutralizing antibody [PDF]
Nature CommunicationsParamyxoviruses including measles, Nipah, and parainfluenza viruses are public health threats with pandemic potential. Human parainfluenza virus type 3 (HPIV3) is a leading cause of illness in pediatric, older, and immunocompromised populations.
Tara C. Marcink +8 more
doaj +2 more sources
Structural basis for dimerization of a paramyxovirus polymerase complex [PDF]
Nature CommunicationsThe transcription and replication processes of non-segmented, negative-strand RNA viruses (nsNSVs) are catalyzed by a multi-functional polymerase complex composed of the large protein (L) and a cofactor protein, such as phosphoprotein (P).
Jin Xie +13 more
doaj +2 more sources
Effect of cyclosporin A on respiratory viral replication in fully differentiated ex vivo human airway epithelia [PDF]
Pharmacology Research & PerspectivesCyclosporin A (CsA), an immunosuppressive drug used in transplant recipients, inhibits graft rejection by binding to cyclophilins and competitively inhibiting calcineurin.
Louise Bondeelle +7 more
doaj +2 more sources
Protective antibodies against human parainfluenza virus type 3 infection
mAbs, 2021 Human parainfluenza virus type III (HPIV3) is a common respiratory pathogen that afflicts children and can be fatal in vulnerable populations, including the immunocompromised. There are currently no effective vaccines or therapeutics available, resulting
Jim Boonyaratanakornkit +10 more
doaj +1 more source
PLoS Pathogens, 2023 The pediatric live-attenuated bovine/human parainfluenza virus type 3 (B/HPIV3)-vectored vaccine expressing the prefusion-stabilized SARS-CoV-2 spike (S) protein (B/HPIV3/S-2P) was previously evaluated in vitro and in hamsters.
Xueqiao Liu +13 more
doaj +1 more source
Identification of the Functional Domain of HPIV3 Matrix Protein Interacting with Nucleocapsid Protein [PDF]
BioMed Research International, 2020 Human parainfluenza virus type 3 (HPIV3) is the main pathogen that causes respiratory infections in infants, young children, and the elderly. Currently, there are no vaccines and effective anti‐infective drugs. Studying the replication and proliferation mechanism of HPIV3 is helpful for exploring the targets of anti‐HPIV3 infection.
Xichuan Deng +7 more
openaire +2 more sources