Results 21 to 30 of about 1,464 (122)
Structure of the uncleaved ectodomain of the paramyxovirus (hPIV3) fusion protein [PDF]
Proceedings of the National Academy of Sciences, 2005 Class I viral fusion proteins share common mechanistic and structural features but little sequence similarity. Structural insights into the protein conformational changes associated with membrane fusion are based largely on studies of the influenza virus hemagglutinin in pre- and postfusion conformations.
Hsien-Sheng, Yin +4 more
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Structure-Guided Improvement of a Dual HPIV3/RSV Fusion Inhibitor [PDF]
Journal of the American Chemical Society, 2019 Human parainfluenza virus 3 (HPIV3) and respiratory syncytial virus (RSV) are leading causes of lower respiratory tract infections. There are currently no vaccines or antiviral therapeutics to treat HPIV3 or RSV infections. We recently reported a peptide (VIQKI), derived from the C-terminal heptad repeat (HRC) domain of the HPIV3 fusion (F ...
Victor K. Outlaw +5 more
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Frontiers in Microbiology, 2021 Human parainfluenza viruses (HPIV1–4) cause acute respiratory tract infections, thereby impacting human health worldwide. However, there are no current effective antivirals or licensed vaccines for infection prevention. Moreover, sequence information for
Nan Shao +11 more
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Protective Antibodies Against Human Parainfluenza Virus Type 3 (HPIV3) Infection [PDF]
, 2020 ABSTRACT Human parainfluenza virus type III (HPIV3) is a common respiratory pathogen that afflicts children and can be fatal in vulnerable populations, including the immunocompromised. Unfortunately, an effective vaccine or therapeutic is not currently available, resulting in tens of thousands of hospitalizations per ...
Jim Boonyaratanakornkit +10 more
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Differential regulation of type I interferon and epidermal growth factor pathways by a human Respirovirus virulence factor. [PDF]
PLoS Pathogens, 2009 A number of paramyxoviruses are responsible for acute respiratory infections in children, elderly and immuno-compromised individuals, resulting in airway inflammation and exacerbation of chronic diseases like asthma.
Grégory Caignard +10 more
doaj +1 more source
The p Value of HPIV3-Mediated Autophagy Inhibition [PDF]
Cell Host & Microbe, 2014 Autophagy, a vesicular pathway involving the lysosomal degradation of cytosolic contents, is frequently hijacked by intracellular pathogens to optimize their infectivity. In this issue of Cell Host & Microbe, Ding et al. (2014) show that human parainfluenza virus exploits autophagy by targeting SNAREs and preventing the SNAP29-Stx17 interaction, an ...
openaire +4 more sources
Virion-Associated Cholesterol Regulates the Infection of Human Parainfluenza Virus Type 3
Viruses, 2019 The matrix (M) proteins of paramyxoviruses bind to the nucleocapsids and cytoplasmic tails of glycoproteins, thus mediating the assembly and budding of virions.
Qiaopeng Tang +3 more
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PLoS Pathogens, 2021 Human parainfluenza virus type 1 (hPIV1) and 3 (hPIV3) cause seasonal epidemics, but little is known about their interaction with human airway cells. In this study, we determined cytopathology, replication, and progeny virion release from human airway ...
Yuki Kurebayashi +6 more
doaj +1 more source
Wellcome Open Research, 2018 Background: Human parainfluenza viruses type 3 (HPIV3) are a prominent cause of respiratory infection with a significant impact in both pediatric and transplant patient cohorts. Currently there is a paucity of whole genome sequence data that would allow
Anna Smielewska +5 more
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PLoS ONE, 2020 Human respiratory syncytial virus (RSV) and parainfluenza virus type 3 (HPIV3) are among the most common viral causes of childhood bronchiolitis and pneumonia worldwide, and lack effective antiviral drugs or vaccines.
Xueqiao Liu +8 more
doaj +1 more source