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Human infection by a bovine strain of parainfluenza virus type 3
Journal of Medical Virology, 1980AbstractEtiological relationship between a bovine strain of parainfluenza virus type 3 and pneumonia in a child is suggested. Haemagglutination inhibition tests have clearly demonstrated that specific antibodies against the bovine virus were present in the patient's serum. The significance of this finding in relation to human infection is discussed.
A Avram, S Yatziv
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Role of Heparan Sulfate in Human Parainfluenza Virus Type 3 Infection
Virology, 2002 Our current studies have demonstrated that human parainfluenza virus type 3 (HPIV-3) utilizes heparan sulfate (HS) for its efficient cellular entry. HPIV-3 interacted with HS-agarose in vitro and the cellular entry and infection of HPIV-3 were reduced following (a) infection of human epithelial lung A549 cells with HPIV-3 pre-incubated with soluble HS;
Santanu Bose, Amiya K Banerjee
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The Catalytic Mechanism of Human Parainfluenza Virus Type 3 Haemagglutinin‐Neuraminidase Revealed
Angewandte Chemie - International Edition, 2015AbstractHuman parainfluenza virus type 3 (hPIV‐3) is one of the leading causes for lower respiratory tract disease in children, with neither an approved antiviral drug nor vaccine available to date. Understanding the catalytic mechanism of human parainfluenza virus haemagglutinin‐neuraminidase (HN) protein is key to the design of specific inhibitors ...
Larissa Dirr +2 more
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Proteins associated with human parainfluenza virus type 3
Journal of Virology, 1985The polypeptides associated with human parainfluenza virus type 3 were identified. Five proteins were present in detergent- and salt-resistant viral cores. Of these, three proteins designated NP0, NP1, and NP2 of 68,000, 58,000, and 52,000 daltons, respectively, were stably associated with 50S RNA in CsCl gradient-purified nucleocapsids. The amounts of
R C, Jambou, N, Elango, S, Venkatesan
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Inoculation of Human Volunteers with Parainfluenza Virus Type 3
JAMA, 1961In an attempt to see whether parainfluenza virus type 3 would produce illness in adults, 28 adult volunteer subjects were inoculated with either the virus or a sterile salt solution. Twelve of the 17 volunteers inoculated with the virus, and none of the 11 who received the placebo inoculum, developed laboratory evidence of infection with parainfluenza ...
A Z, KAPIKIAN +5 more
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Liver Enzyme Elevation Related to Human Parainfluenza Virus Type 3 Infection
Pediatric Infectious Disease Journal, 2022The human parainfluenza viruses are common causes of upper and lower respiratory tract infection; however, nonrespiratory infections with human parainfluenza viruses are rare, and there are no reports of pediatric cases of liver enzyme elevation. We present 2 pediatric patients who developed liver enzyme elevation related to human parainfluenza virus ...
Yoshimasa Kudo +5 more
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Intracellular synthesis of human parainfluenza type 3 virus-specified polypeptides
Journal of Virology, 1985The intracellular synthesis of human parainfluenza type 3 virus-specified polypeptides was examined by polyacrylamide gel electrophoresis of [35S]methionine-labeled cell extracts under reducing conditions. All of the virion structural proteins were detected in cell extracts, including: L, 180,000 molecular weight (180K); P, 83K; HN, 69K; NP, 66K; F0 ...
S L, Wechsler +3 more
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Journal of Infectious Diseases, 1988
Bovine parainfluenza virus type 3 (PIV-3) was evaluated as a candidate live-virus vaccine to protect against infection with human PIV-3. The level of replication of bovine and human PIV-3 and the efficacy of immunization with bovine PIV-3 in protecting against subsequent challenge with human PIV-3 was evaluated in nonhuman primates.
K L, van Wyke Coelingh +4 more
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Bovine parainfluenza virus type 3 (PIV-3) was evaluated as a candidate live-virus vaccine to protect against infection with human PIV-3. The level of replication of bovine and human PIV-3 and the efficacy of immunization with bovine PIV-3 in protecting against subsequent challenge with human PIV-3 was evaluated in nonhuman primates.
K L, van Wyke Coelingh +4 more
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Sulfatide negatively regulates the fusion process of human parainfluenza virus type 3
Journal of Biochemistry, 2012Sulfatide (HSO(3)-3-galactosylceramide), which enriched in lipid rafts of plasma membranes in various epithelial cell lines, is a critical component of host cells for effective production of influenza A virus. However, the function of sulfatide in other virus infections targeting epithelial cells remains unknown.
Tadanobu, Takahashi +6 more
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Regulation of human parainfluenza virus type 3 transcription.
2009To elucidate the roles of the junctional elements in HPIV3 transcription, cDNAs were constructed containing CAT and luciferase reporter genes flanked by sequences representing the HPIV3 termini necessary for transcription, replication and packaging. Mutations to the gene end sequence abolished expression of the upstream and downstream genes.
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