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Mapping of an Antigenic Site on the Nucleocapsid Protein of Human Parainfluenza Virus Type 3
Viral Immunology, 2009Human parainfluenza virus type 3 (hPIV3) is a respiratory tract pathogen. The current study aimed to investigate immunodominant regions of hPIV3 nucleocapsid (N) protein by using monoclonal antibodies (mAbs) raised against recombinant N protein and human serum specimens from hPIV3-infected individuals.
Aurelija, Zvirbliene +5 more
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Antigenic and functional organization of human parainfluenza virus type 3 fusion glycoprotein
Journal of Virology, 1989Twenty-six monoclonal antibodies (MAbs) (14 neutralizing and 12 nonneutralizing) were used to examine the antigenic structure, biological properties, and natural variation of the fusion (F) glycoprotein of human type 3 parainfluenza virus (PIV3). Analysis of laboratory-selected antigenic variants and of PIV3 clinical isolates indicated that the panel ...
K, van Wyke Coelingh, E L, Tierney
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Journal of Infectious Diseases, 1985
The envelope glycoproteins of human parainfluenza type 3 virus were characterized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and reactivity with specific monoclonal antibodies. The molecular weight of the hemagglutinin-neuraminidase (HN) glycoprotein was found to be 72,000, and the fusion (F) glycoprotein appeared to consist of 74,000
R, Ray, V E, Brown, R W, Compans
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The envelope glycoproteins of human parainfluenza type 3 virus were characterized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and reactivity with specific monoclonal antibodies. The molecular weight of the hemagglutinin-neuraminidase (HN) glycoprotein was found to be 72,000, and the fusion (F) glycoprotein appeared to consist of 74,000
R, Ray, V E, Brown, R W, Compans
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Intranasal Immunization of Hamsters with Envelope Glycoproteins of Human Parainfluenza Virus Type 3
Journal of Infectious Diseases, 1988Envelope glycoproteins of human parainfluenza virus type 3 (PIV-3) were selectively solubilized with n-octyl beta-D-glucopyranoside and reconstituted into lipid vesicles by dialysis of the detergent. The efficacy of the glycoprotein preparation as a subunit vaccine when administered to hamsters intranasally or subcutaneously was compared.
R, Ray +3 more
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Antigenic variation in the hemagglutinin-neuraminidase protein of human parainfluenza type 3 virus
Virology, 1985Sixteen monoclonal antibodies directed to the hemagglutinin-neuraminidase (HN) protein of a 1957 isolate of parainfluenza type 3 virus (PIV3) were produced and used to examine antigenic variation in clinical strains. Analysis of hemagglutination-inhibition reactivity patterns of antigenic variants selected in vitro in the presence of monoclonal ...
K L, van Wyke Coelingh +2 more
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Rescue of Synthetic Analogs of Genome RNA of Human Parainfluenza Virus Type 3
Virology, 1993A simple system that allows expression and packaging of a foreign gene by human parainfluenza virus type 3 (HPIV-3) has been described. First, a cDNA was constructed to encode an internally deleted version of HPIV-3 genome RNA. The viral genes were replaced with a negative sense copy of the bacterial chloramphenicol acetyl transferase (CAT) reporter ...
B P, De, A K, Banerjee
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The DI–DII linker of human parainfluenza virus type 3 fusion protein is critical for the virus
Virus Genes, 2019Human parainfluenza virus type 3 (HPIV3) causes the majority of childhood viral pneumonia around the world. Fusing the viral and target cell membranes is crucial for its entry into target cells, and the fusion process requires the concerted actions of two viral glycoproteins: hemagglutinin-neuraminidase (HN) and fusion (F) protein. After binding to the
Ying, Liu +7 more
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ISGylation during Human Parainfluenza Virus Type 3 Infection
The Journal of ImmunologyAbstract Human parainfluenza virus type 3 (HPIV3) causes lower respiratory illnesses such as pneumonia or bronchiolitis in infants, young children, and the immunocompromised. HPIV3 associated airway inflammatory diseases manifest as a result of host mediated exaggerated inflammatory response, though limited knowledge exists regarding ...
Lindsay Miller +3 more
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Lentivirus vector pseudotyped with human parainfluenza virus type 3 glycoproteins
Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology, 2003Lentiviral vectors pseudotyped with the envelope glycoproteins of amphotropic murine leukemia virus and the G protein of vesicular stomatitis virus have been previously developed for use in human gene therapy trials. We report here the generation of infectious replication-defective HIV-1 particles pseudotyped with hemagglutinin-neuraminidase (HN) and ...
B. Grzybowski +3 more
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Characterization of the fusion protein of the human parainfluenza virus type 3
2013Human parainfluenza virus type 3 (HPIV3), a member of the family Paramyxoviridae, is an enveloped, negative-sense single stranded RNA virus, and an important cause of upper and lower respiratory tract disease in children. Infection by HPIV3 requires fusion of the viral envelope with the plasma membrane of the host cell.
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