Results 71 to 80 of about 44,207 (161)

The structural basis of protective and nonprotective human monoclonal antibodies targeting the parainfluenza virus type 3 hemagglutinin-neuraminidase

Nature Communications
Parainfluenza virus 3 (PIV3) infection poses a substantial risk to vulnerable groups including infants, the elderly, and immunocompromised individuals, and lacks effective treatments or vaccines.
Rose J. Miller, Ian A. Durie, Aaron D. Gingerich, Mohamed A. Elbehairy, Abigail G. Branch, Riley G. Davis, Nada Abbadi, Melinda A. Brindley, Jarrod J. Mousa   +8 more
doaj   +1 more source

Genetic analysis of human parainfluenza virus type 3 obtained in Croatia, 2011–2015

Journal of Medical Microbiology, 2017
This study investigated the HPIV3 circulating strains in Croatia and whether the other parts of HPIV3 genome (F gene and HN 582 nucleotides fragment) could be equally suitable for genetic and phylogenetic analysis.Clinical materials were collected in period 2011-2015 from children suffering from respiratory illnesses.
Košutić-Gulija, Tanja, Slovic, Anamarija, Ljubin-Sternak, Sunčanica, Mlinarić-Galinović, Gordana, Forčić, Dubravko   +4 more
openaire   +3 more sources

Exportin-1-Dependent Nuclear Export of DEAD-box Helicase DDX3X is Central to its Role in Antiviral Immunity

Cells, 2019
DEAD-box helicase 3, X-linked (DDX3X) regulates the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR)-mediated antiviral response, but can also be a host factor contributing to the replication of viruses of significance to human health, such as ...
Steven M. Heaton, Sarah C. Atkinson, Melissa N. Sweeney, Sundy N. Y. Yang, David A. Jans, Natalie A. Borg   +5 more
doaj   +1 more source

A robust mouse model of HPIV-3 infection and efficacy of GS-441524 against virus-induced lung pathology

Nature Communications
Human parainfluenza virus type 3 (HPIV-3) can cause severe respiratory tract infections. There are no convenient small-animal infection models. Here, we show viral replication in the upper and lower airways of AG129 mice (double IFNα/β and IFNγ receptor ...
Yuxia Lin, Mona Khan, Birgit Weynand, Manon Laporte, Frank Coenjaerts, Darius Babusis, John P. Bilello, Peter Mombaerts, Dirk Jochmans, Johan Neyts   +9 more
doaj   +1 more source

Nosocomial human parainfluenza virus type 3 outbreak in immunocompromised patients, and possible lessons from the SARS-CoV-2 pandemic. [PDF]

J Hosp Infect, 2022
Gürtler N, Osthoff M, Egli A, Halter J, Khanna N, Tschudin-Sutter S, Bassetti S.   +6 more
europepmc   +1 more source

Interaction between the Hemagglutinin-Neuraminidase and Fusion Glycoproteins of Human Parainfluenza Virus Type III Regulates Viral Growth In Vivo

mBio, 2013
Paramyxoviruses, enveloped RNA viruses that include human parainfluenza virus type 3 (HPIV3), cause the majority of childhood viral pneumonia. HPIV3 infection starts when the viral receptor-binding protein engages sialic acid receptors in the lung and ...
Rui Xu, Samantha G. Palmer, Matteo Porotto, Laura M. Palermo, Stefan Niewiesk, Ian A. Wilson, Anne Moscona   +6 more
doaj   +1 more source

Paramyxovirus matrix protein redirects METTL3 for dual regulation of viral replication and immune evasion.

PLoS Pathogens
N6-methyladenosine (m6A) epitranscriptomic modifications play crucial roles in regulating both host and viral gene expression. Here, we revealed a novel mechanism by which paramyxoviruses exploit host m6A machinery to simultaneously enhance viral ...
Takashi Okura, Yusuke Nakai, Taichi Kameya, Fuminori Mizukoshi, Hiyori Okura, Masatoshi Kakizaki, Fumihiro Kato, Yusuke Matsumoto, Yuichiro Nakatsu, Kaoru Takeuchi, Hirokazu Kimura, Makoto Takeda, Noriyuki Otsuki, Kazuya Shirato, Hideki Hasegawa, Akihide Ryo   +15 more
doaj   +1 more source

Human Coronaviruses HCoV-NL63 and HCoV-HKU1 in Hospitalized Children with Acute Respiratory Infections in Beijing, China

Advances in Virology, 2011
The human coronaviruses (HCoVs) HCoV-NL63 and HCoV-HKU1 are two recently discovered coronaviruses that circulate widely and are associated with acute respiratory infections (ARI).
Li-Jin Cui, Chen Zhang, Ting Zhang, Rou-Jian Lu, Zheng-De Xie, Ling-Lin Zhang, Chuan-Yan Liu, Wei-Min Zhou, Li Ruan, Xue-Jun Ma, Wen-Jie Tan   +10 more
doaj   +1 more source

Unraveling dynamics of paramyxovirus-receptor interactions using nanoparticles displaying hemagglutinin-neuraminidase.

PLoS Pathogens
Sialoglycan-binding enveloped viruses often possess receptor-destroying activity to avoid being immobilized by non-functional decoy receptors. Sialic acid (Sia)-binding paramyxoviruses contain a hemagglutinin-neuraminidase (HN) protein that possesses ...
Xuesheng Wu, Maite Goebbels, Oliver Debski-Antoniak, Katherine Marougka, Lemeng Chao, Tony Smits, Tom Wennekes, Frank J M van Kuppeveld, Erik de Vries, Cornelis A M de Haan   +9 more
doaj   +1 more source

Curcumin Inhibits Replication of Human Parainfluenza Virus Type 3 by Affecting Viral Inclusion Body Formation. [PDF]

Biomed Res Int, 2021
Zhang C, Zhang K, Zang G, Chen T, Lu N, Wang S, Zhang G.   +6 more
europepmc   +1 more source