Results 61 to 70 of about 12,861,632 (309)

THE PECULIARITIES OF HUMAN PHYSICAL LABOR IN EXTREME ENVIRONMENTAL CONDITIONS

Physical Culture Sport Tourism Motor Recreation
The development of scientifi c and technological progress exacerbates the contradictions between society and nature, expanding the boundaries of environmental exploitation and human settlement. The intensity of the use of natural resources is due to large-scale human activity in high latitudes, within the coastal shelf and in desert regions.
MIKHAIL ALEXANDROVICH BOKAREV, ALEXANDER MIKHAILOVICH FOKIN, MIKHAIL MIKHAILOVICH BOKAREV   +2 more
openaire   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Predicting differential ratings of perceived exertion (dRPE) in youth soccer using decision tree models

Scientific Reports
This study investigated the relationship between external training load metrics obtained from GPS technology and differentiated ratings of perceived exertion (dRPE) in elite youth soccer players, and evaluated the predictive value of decision tree models
Robert Śliwowski, Tomasz Górecki, Michał Włodarczyk, Thierry Paillard, Teresa Zwierko, Jakub Marynowicz   +5 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Assessment of cool thermal storage strategies in Kuwait [PDF]

, 2006
The extensive use of air conditioning for indoor cooling in offices and large commercial buildings in Kuwait represents a major part of the power and electricity consumption in that country.
Sebzali, Mohamed
core   +4 more sources

The study of physical condition of settlement in Penjaringan – Jakarta to build liveable human settlement

IOP Conference Series: Earth and Environmental Science, 2020
Abstract High population growth due to urbanization has led to the emergence of many densely populated and uninhabitable settlements in Jakarta. Jakarta has 445 RWs which are categorized as unfit for habitation, one of which is the Penjaringan sub-district, and the government will organize it.
S M Aror, N Nurdiani, W Katarina
openaire   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Geothermal- And Solar Assisted Air Conditioning System [PDF]

, 2012
A research project of the Hamburg University of Technology realizes an open cycle desiccant assisted air conditioning system based on renewable heat sources e.g. solar thermal and heat sinks e.g. shallow geothermal energy.
Wrobel, Jan, Schmitz, Gerhard
core   +1 more source