Results 11 to 20 of about 280,925 (351)

The Importance of Imprinting in the Human Placenta [PDF]

PLoS Genetics, 2010
As a field of study, genomic imprinting has grown rapidly in the last 20 years, with a growing figure of around 100 imprinted genes known in the mouse and approximately 50 in the human. The imprinted expression of genes may be transient and highly tissue-specific, and there are potentially hundreds of other, as yet undiscovered, imprinted transcripts ...
Frost, JM, Moore, GE
openaire   +9 more sources

Telomeric NAP1L4 and OSBPL5 of the KCNQ1 cluster, and the DECORIN gene are not imprinted in human trophoblast stem cells [PDF]

, 2010
Background: Genomic imprinting of the largest known cluster, the Kcnq1/KCNQ1 domain on mChr7/hChr11, displays significant differences between mouse and man.
Frost, J.M., Moore, G.E., Moore, H.D., Udayashankar, R.   +3 more
core   +11 more sources

Placental development and preeclampsia

生物医学转化, 2022
Serving as the interface between the fetal and maternal environment during gestation, the placenta plays critical roles in the protection of the developing fetus and the maintenance of pregnancy.
Zhu Yuelin, Li Qianqian, Wang Yanling, Shao Xuan   +3 more
doaj   +1 more source

Biological behaviors of muscarinic receptors in mesenchymal stem cells derived from human placenta and bone marrow [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): Cells perform their functional activities by communicating with each other through endogenous substances and receptors. Post-translation, stem cells function properly in new host tissue by carrying specific cell surface receptors.
Arash Alizadeh Yegani, Erkan Maytalman, Ilknur Kozanoglu, Menderes Yusuf Terzi, Fazilet Aksu   +4 more
doaj   +1 more source

Human Placental Endothelial Cell and Trophoblast Heterogeneity and Differentiation Revealed by Single-Cell RNA Sequencing

Cells, 2022
Background: The placenta is an important organ for fetal and maternal health during pregnancy and impacts offspring health late in life. Defects in placental vasculature and trophoblast have been identified in several pregnancy complications.
Han Li, Hao Peng, Wei Hong, Yingying Wei, Haojun Tian, Xiaojie Huang, Linyan Jia, Jing Zheng, Tao Duan, Qizhi He, Kai Wang   +10 more
doaj   +1 more source

Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Mesenchymal Stem/Stromal Cells Derived from Human Placenta

Frontiers in Cell and Developmental Biology, 2022
Mesenchymal stem/stromal cells derived from placenta (PMSCs) are an attractive source for regenerative medicine because of their multidifferentiation potential and immunomodulatory capabilities.
Jinlu Li, Jinlu Li, Quanlei Wang, Quanlei Wang, Yanru An, Xiaoyan Chen, Yanan Xing, Yanan Xing, Qiuting Deng, Qiuting Deng, Zelong Li, Zelong Li, Shengpeng Wang, Shengpeng Wang, Xi Dai, Xi Dai, Ning Liang, Yong Hou, Huanming Yang, Huanming Yang, Zhouchun Shang, Zhouchun Shang, Zhouchun Shang   +22 more
doaj   +1 more source

Comparative Study of PPARγ Targets in Human Extravillous and Villous Cytotrophoblasts

PPAR Research, 2020
Trophoblasts, as the cells that make up the main part of the placenta, undergo cell differentiation processes such as invasion, migration, and fusion.
Fulin Liu, Christine Rouault, Mickael Guesnon, Wencan Zhu, Karine Clément, Séverine A. Degrelle, Thierry Fournier   +6 more
doaj   +1 more source

The human placenta methylome [PDF]

Proceedings of the National Academy of Sciences, 2013
Tissue-specific DNA methylation is found at promoters, enhancers, and CpG islands but also over larger genomic regions. In most human tissues, the vast majority of the genome is highly methylated (>70%). Recently, sequencing of bisulfite-treated DNA (MethylC-seq) has revealed large partially methylated domains (PMDs) in some human cell lines.
Paul Ashwood, John D. Blair, Wendy P. Robinson, Hung On Ken Yu, Paul Lott, Danna Hong, Diane I. Schroeder, Janine M. LaSalle, Ian F Korf, Cheryl Walker, Florence K. Crary   +10 more
openaire   +2 more sources

Coordinated Expressional Landscape of the Human Placental miRNome and Transcriptome

Frontiers in Cell and Developmental Biology, 2021
Placenta is a unique organ that serves its own function, and contributes to maternal gestational adaptation and fetal development. Coordination of its transcriptome to satisfy all the maternal-fetal needs across gestation is not fully understood ...
Rain Inno, Triin Kikas, Kristiina Lillepea, Maris Laan   +3 more
doaj   +1 more source

Establishment of the fetal-maternal interface: developmental events in human implantation and placentation

Frontiers in Cell and Developmental Biology, 2023
Early pregnancy is a complex and well-orchestrated differentiation process that involves all the cellular elements of the fetal-maternal interface. Aberrant trophoblast-decidual interactions can lead to miscarriage and disorders that occur later in ...
Chien-Chu Huang, Ya-Wen Hsueh, Chia-Wei Chang, Hsi-Chen Hsu, Tung-Chuan Yang, Wu-Chou Lin, Hsun-Ming Chang   +6 more
doaj   +1 more source