The endogenous production of hydrogen sulphide in intrauterine tissues [PDF]
, 2009 Background: Hydrogen sulphide is a gas signalling molecule which is produced endogenously from L-cysteine via the enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).
Carson, Ray J. +4 more
core +5 more sources
Trophoblast lineage-specific differentiation and associated alterations in preeclampsia and fetal growth restriction. [PDF]
, 2020 The human placenta is a poorly-understood organ, but one that is critical for proper development and growth of the fetus in-utero. The epithelial cell type that contributes to primary placental functions is called "trophoblast," including two main ...
Farah, Omar +3 more
core +2 more sources
ANNEXIN A1: Roles in Placenta, Cell Survival, and Nucleus
Cells, 2022 The unbiased approaches of the last decade have enabled the collection of new data on the biology of annexin A1 (ANXA1) in a variety of scientific aspects, creating opportunities for new biomarkers and/or therapeutic purposes.
Stefanie Oliveira de Sousa +4 more
doaj +1 more source
The variation in transparency of amniotic membrane used in ocular surface regeneration [PDF]
, 2010 Background/aims: Scant consideration has been given to the variation in structure of the human amniotic membrane (AM) at source or to the significance such differences might have on its clinical transparency.
Chen, Bo +7 more
core +1 more source
Unique features and emerging in vitro models of human placental development
Reproductive Medicine and Biology, 2020 Background The placenta is an essential organ for the normal development of mammalian fetuses. Most of our knowledge on the molecular mechanisms of placental development has come from the analyses of mice, especially histopathological examination of ...
Shun Shibata +5 more
doaj +1 more source
Placental syncytiotrophoblast constitutes a major barrier to vertical transmission of Listeria monocytogenes. [PDF]
, 2010 Listeria monocytogenes is an important cause of maternal-fetal infections and serves as a model organism to study these important but poorly understood events. L.
A Beham +82 more
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Modeling the variability of shapes of a human placenta [PDF]
, 2008 While it is well-understood what a normal human placenta should look like, a deviation from the norm can take many possible shapes. In this paper we propose a mechanism for this variability based on the change in the structure of the vascular ...
Adair +49 more
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Oxidative stress stimulates alpha-tocopherol transfer protein in human trophoblast tumor cells BeWo [PDF]
, 2012 alpha-Tocopherol transfer protein (alpha-TTP) has been identified as the major intracellular transport protein for the antioxidant vitamin E (alpha-Tocopherol).
Etzl, Ronny P. +7 more
core +1 more source
Frontiers in Immunology, 2021 The syncytiotrophoblast (STB) of human placenta constitutively and throughout pregnancy produces and secretes exosomes - nanometer-sized membrane-bound extracellular vesicles from the endosomal compartment that convey cell-cell contact ‘by proxy ...
Lucia Mincheva-Nilsson
doaj +1 more source
Fetal-derived trophoblast use the apoptotic cytokine tumor necrosis factor-alpha-related apoptosis-inducing ligand to induce smooth muscle cell death. [PDF]
, 2007 Remodeling of the uterine spiral arteries during pregnancy transforms them from high to low resistance vessels that lack vasoconstrictive properties. This process is essential to meet the demand for increased blood flow imposed by the growing fetus. Loss
Aplin, JD +6 more
core +1 more source