Results 21 to 30 of about 8,929,794 (358)

Changes in mitochondrial respiration in the human placenta over gestation

Placenta, 2017
Olivia J. Holland, Anthony J. Hickey, Anna Alvsaker, Stéphanie Moran, Christopher P. Hedges, Larry Chamley, Anthony V. Perkins   +6 more
openalex   +3 more sources

Trophoblast lineage-specific differentiation and associated alterations in preeclampsia and fetal growth restriction. [PDF]

, 2020
The human placenta is a poorly-understood organ, but one that is critical for proper development and growth of the fetus in-utero. The epithelial cell type that contributes to primary placental functions is called "trophoblast," including two main ...
Farah, Omar, Nguyen, Calvin, Parast, Mana M, Tekkatte, Chandana   +3 more
core   +2 more sources

Mesenchymal Stromal Cells from Fetal and Maternal Placenta Possess Key Similarities and Differences: Potential Implications for Their Applications in Regenerative Medicine

Cells, 2020
Placenta-derived mesenchymal stromal cells (MSC) have attracted more attention for their immune modulatory properties and poor immunogenicity, which makes them suitable for allogeneic transplantation.
Andrea Papait, Elsa Vertua, Marta Magatti, Sabrina Ceccariglia, Silvia De Munari, Antonietta Rosa Silini, Michal Sheleg, Racheli Ofir, Ornella Parolini   +8 more
doaj   +1 more source

Human Placental Endothelial Cell and Trophoblast Heterogeneity and Differentiation Revealed by Single-Cell RNA Sequencing

Cells, 2022
Background: The placenta is an important organ for fetal and maternal health during pregnancy and impacts offspring health late in life. Defects in placental vasculature and trophoblast have been identified in several pregnancy complications.
Han Li, Hao Peng, Wei Hong, Yingying Wei, Haojun Tian, Xiaojie Huang, Linyan Jia, Jing Zheng, Tao Duan, Qizhi He, Kai Wang   +10 more
doaj   +1 more source

The endogenous production of hydrogen sulphide in intrauterine tissues [PDF]

, 2009
Background: Hydrogen sulphide is a gas signalling molecule which is produced endogenously from L-cysteine via the enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).
Carson, Ray J., Heptinstall, John, Patel, Pushpa, Vatish, Manu, Wang, Rui   +4 more
core   +5 more sources

Pivotal role of the transcriptional co-activator YAP in trophoblast stemness of the developing human placenta

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Defects in development and differentiation of the placenta are associated with various pregnancy disorders such as miscarriage, stillbirth, preeclampsia, and intrauterine growth restriction.
G. Meinhardt, S. Haider, V. Kunihs, L. Saleh, J. Pollheimer, C. Fiala, Szabolcs Hetey, Zsofia Feher, A. Szilágyi, N. Than, M. Knöfler   +10 more
semanticscholar   +1 more source

The variation in transparency of amniotic membrane used in ocular surface regeneration [PDF]

, 2010
Background/aims: Scant consideration has been given to the variation in structure of the human amniotic membrane (AM) at source or to the significance such differences might have on its clinical transparency.
Chen, Bo, Connon, Che John, Doutch, James, Hopkinson, Andy, Kinoshita, Shigeru, Meek, Keith, Mehta, Jod, Nakamura, Takahiro   +7 more
core   +1 more source

Oxygen and development of the human placenta.

Reproduction, 2020
Development of the human placenta takes place in contrasting oxygen concentrations at different stages of gestation, from ~20 mmHg during the first trimester rising to ~60 mmHg at the start of the second trimester before gradually declining to ~40 mmHg ...
G. Burton, T. Cindrova-Davies, H. Yung, E. Jauniaux   +3 more
semanticscholar   +1 more source

Fetal-derived trophoblast use the apoptotic cytokine tumor necrosis factor-alpha-related apoptosis-inducing ligand to induce smooth muscle cell death. [PDF]

, 2007
Remodeling of the uterine spiral arteries during pregnancy transforms them from high to low resistance vessels that lack vasoconstrictive properties. This process is essential to meet the demand for increased blood flow imposed by the growing fetus. Loss
Aplin, JD, Baker, PN, Cartwright, JE, Freeman, A, Harris, LK, Keogh, RJ, Whitley, GS   +6 more
core   +1 more source

Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?

bioRxiv, 2020
The pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected over 3.8 million people, including pregnant women.
R. Pique-Regi, R. Romero, A. Tarca, Francesca Luca, Yi Xu, A. Alazizi, Y. Leng, Chaur-Dong Hsu, N. Gomez‐Lopez   +8 more
semanticscholar   +1 more source