Results 61 to 70 of about 229,879 (262)

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, EarlyView.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Morphology of the villous chorion maldevelopment in early forms of EPH-gestosis combined with anemia of pregnancy

Patologìâ, 2012
On the basis of a complex morphological study of human placenta the characteristic structural features of villous maldevelopment in a combination of edema of pregnant and anemia of pregnancy are defined by the type of dissociated cotyledon development ...
N. M. Lagoda
doaj   +1 more source

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

Advanced Science, EarlyView.
CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu, Zhou Jing Zhang, Jing Jin, Hai Yuan Xu, Ya Xin Gu, Qian Qian Yang, You Lang Zhou   +6 more
wiley   +1 more source

Myogenic Differentiation on 3D‐Printed Interpenetrating Bioactive Hydrogel of Decellularised Human Placenta With Fish Scale Gelatin

MedComm – Biomaterials and Applications
Tissue‐specific templates are essential for muscle differentiation as they enhance cell alignment and regeneration. Advancements in extrusion 3D printing with biomaterial inks enable customizable designs and tailored spatial arrangements.
Asmita Biswas, Ragavi Rajasekaran, Pravin Vasudeo Vaidya, Atul Kumar Ojha, Suman Mishra, Sayan Mukherjee, Saikat Biswas, Nantu Dogra, Padmavati Manchikanti, Santanu Dhara   +9 more
doaj   +1 more source

Heavy Metal Contamination: Impacts From Plants to the Food Chain and Eco‐Friendly Amelioration Strategies

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Heavy metal pollution reduces soil health and threatens food safety by entering plants; however, the use of nanoparticles, biofertilizers, and organic fertilizers such as biochar offers a promising strategy for improvement and sustainable agriculture. ABSTRACT Heavy metal (HM) pollution, resulting from human activities such as mining and the excessive ...
Sina Siavash Moghaddam, Latifeh Pourakbar, Sevda Alizadeh, Zahra Alizadeh, Jelena Popović‐Djordjević   +4 more
wiley   +1 more source

Placental growth factor and apoptosis as early prognostic factor of placental insufficiency

Journal of Education, Health and Sport, 2015
Filonenko T.G., Davydova A.A., Ermola Yu.A., Nechiporenko G.V., Shalanin V.V., Syurina N.A., Menshikova O.P., Kuzmin M.N., Fedotov V.V., Beketov A.A. Placental growth factor and apoptosis as early prognostic factor of placental insufficiency. Journal of
T. G. Filonenko, A. A. Davydova, Yu. A. Ermola, V. V. Nechiporenko, V. V. Shalanin, N. A. Syurina, O. P. Menshikova, M. N. Kuzmin, V. V. Fedotov, A. A. Beketov   +9 more
doaj  

Proteomic Epithelial‐To‐Mesenchymal Transition Signature in Fetoplacental Small Extracellular Vesicles of Early‐Onset Preeclampsia

Journal of Extracellular Biology
Preeclampsia (PE), a hypertensive disorder in pregnancy, is linked to placental vascular remodelling, increasing risks of foetal growth restriction and long‐term offspring health problems.
Michaela Stoiber, Monika Horvat Mercnik, Birgit Hirschmugl, Barbara Darnhofer, Dominique Pernitsch, Barbara Leopold‐Posch, Ursula Hiden, Dagmar Kolb, Christian Wadsack   +8 more
doaj   +1 more source