Results 81 to 90 of about 8,929,794 (358)
Blood flow and transport in the human placenta.
Annual Review of Fluid Mechanics, 2019 The placenta is a multi-functional organ that exchanges blood gases and nutrients between a mother and her developing fetus. In humans, fetal blood flows through intricate networks of vessels confined within villous trees, the branches of which are ...
O. Jensen, I. Chernyavsky
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.A novel method that combines 3D printing and organ‐on‐chip technology enables the creation of hollow channels lined with endothelial cells through a fibroblast‐populated connective tissue matrix. The model supports stable metabolic culture conditions, angiogenic sprouting, and immune cell migration, thereby demonstrating an easy and versatile method to
Jonas Jäger +7 more
wiley +1 more source
Optimal villi density for maximal oxygen uptake in the human placenta
, 2015 We present a stream-tube model of oxygen exchange inside a human placenta functional unit (a placentone). The effect of villi density on oxygen transfer efficiency is assessed by numerically solving the diffusion-convection equation in a 2D+1D geometry ...
Brownbill, P. +4 more
core +1 more source
Sex differences in the late first trimester human placenta transcriptome
Biology of Sex Differences, 2018 Development of the placenta during the late first trimester is critical to ensure normal growth and development of the fetus. Developmental differences in this window such as sex-specific variation are implicated in later placental disease states, yet ...
Tania L. Gonzalez +14 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.This study develops a placenta‐targeted nanodelivery system co‐loading HMGB1 protein and the NLRP3 agonist nigericin to establish an animal model of atonic postpartum hemorrhage. The model accurately recapitulates clinical phenotypes, including prolonged labor and uterine contractility dysfunction, while revealing inflammatory activation in placental ...
Jiangxue Qu +10 more
wiley +1 more source
Veterinary Medicine and Science, 2022 Background Hepatocellular carcinoma (HCC) is the fifth most diagnosed cancer and the second leading cause of cancer‐related deaths worldwide. Sorafenib is the standard treatment used in the advanced stages of HCC. Cell therapy with mesenchymal stem cells
Saieh Hajighasemlou +8 more
doaj +1 more source
Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs
Advanced Healthcare Materials, EarlyView.Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner +8 more
wiley +1 more source
Development of the Human Placenta and Fetal Heart: Synergic or Independent?
Frontiers in Physiology, 2018 The placenta is the largest fetal organ, and toward the end of pregnancy the umbilical circulation receives at least 40% of the biventricular cardiac output.
G. Burton, E. Jauniaux
semanticscholar +1 more source
Advances in Bioprinting to Model Immune‐Mediated Skin Diseases
Advanced Healthcare Materials, EarlyView.This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández +4 more
wiley +1 more source
Defense and infection of the human placenta
Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 2018 The placenta functions as a shield against infection of the fetus. The innate and adaptive immune defenses of the developing fetus are poorly equipped to fight infections.
Amy E Heerema-McKenney
semanticscholar +1 more source