Results 131 to 140 of about 5,283,554 (314)

Strength of evidence for paternal influence on offspring epigenome in observational human studies: a systematic review and risk-of-bias appraisal for non-randomized exposures

Epigenetics
Paternal influence on the offspring epigenome is difficult to interpret in observational human studies due to heterogeneous designs, causing varying susceptibility to bias and non-causal explanations.
Ka Kei Sum, Mark A. Burton, Cristina Garcia-Maurino Alcazar, Ai Ling Teh, Keith M. Godfrey, Jonathan Yinhao Huang   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Long-read assembly reveals vast transcriptional complexity in the placenta associated with metabolic and endocrine function

Nature Communications
The placenta is critical for fetal development and mediates effects of pregnancy complications on offspring metabolic health yet remains poorly characterized in genomic studies. Existing transcriptomic analyses rely on adult tissue reference annotations,
Sean T. Bresnahan, Hannah E. J. Yong, Aryun Nemani, William H. Wu, Sierra Lopez, Jerry Kok Yen Chan, Frédérique White, Pierre-Étienne Jacques, Marie-France Hivert, Shiao-Yng Chan, Michael I. Love, Jonathan Y. Huang, Arjun Bhattacharya   +12 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

World report: 2016

, 2016
World Report 2016 summarizes key human rights issues in more than 90 countries and territories worldwide. It reflects investigative work that Human Rights Watch staff undertook in 2015, usually in close partnership with human rights activists in the ...
Human Rights Watch
core  

Developing Creativity to Enhance Human Potential in Sport: A Wicked Transdisciplinary Challenge. [PDF]

Front Psychol, 2019
Vaughan J, Mallett CJ, Davids K, Potrac P, López-Felip MA.   +4 more
europepmc   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

The future of human rights impact assessments of trade agreements

, 2009
The Future of Human Rights Impact Assessments of Trade Agreements develops a methodology for human rights impact assessments of trade agreements and considers whether there is any value in using the methodology on a sustained basis to ensure that the ...
Studie- en Informatiecentrum Mensenrecht, Human Rights in a World of Conflict and Diversity. Conceptualisation and Implementation of Human Rights (t/m 2009), Walker, S.M.   +2 more
core  

In vivo behaviour of human precursors into a dystrophic context [PDF]

, 2013
The Duchenne Muscular Dystrophy (DMD) is a lethal recessive X-linked disease caused by mutations in the dystrophin gene, no effective treatment is available up to date.
Vallese, Denis
core  

Well-Being With Soul: Science in Pursuit of Human Potential. [PDF]

Perspect Psychol Sci, 2018
Ryff CD.
europepmc   +1 more source