Results 111 to 120 of about 5,283,554 (314)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Short-term diet intervention comprising of olive oil, vitamin D, and omega-3 fatty acids alters the small non-coding RNA (sncRNA) landscape of human sperm

Scientific Reports
Offspring health outcomes are often linked with epigenetic alterations triggered by maternal nutrition and intrauterine environment. Strong experimental data also link paternal preconception nutrition with pathophysiology in the offspring, but the ...
Candida Vaz, Mark Burton, Alexandra J. Kermack, Pei Fang Tan, Jason Huan, Tessa P. X. Yoo, Kerry Donnelly, Susan J. Wellstead, Dennis Wang, Helena L. Fisk, Franchesca D. Houghton, Sheena Lewis, Yap Seng Chong, Peter D. Gluckman, Ying Cheong, Nicholas S. Macklon, Philip C. Calder, Anindya Dutta, Keith M. Godfrey, Pankaj Kumar, Karen A. Lillycrop, Neerja Karnani   +21 more
doaj   +1 more source

Characterisation of pregnancy-induced alterations in apolipoproteins and their associations with maternal metabolic risk factors and offspring birth outcomes: a preconception and longitudinal cohort studyResearch in context

EBioMedicine
Summary: Background: Apolipoproteins as an integral part of lipoproteins are crucial for the transport and metabolism of lipids. However, there is a lack of longitudinal studies to quantify the concentrations of maternal apolipoproteins from ...
Li Chen, Karen Mei-Ling Tan, Melvin Khee-Shing Leow, Kok Hian Tan, Jerry Kok Yen Chan, Shiao-Yng Chan, Yap Seng Chong, Peter D. Gluckman, Johan G. Eriksson, Markus R. Wenk, Sartaj Ahmad Mir   +10 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

A Review of the Potential Impacts of the Métis Human Resources Development Agreements in Canada [PDF]

Since 1999, thousands of Métis have received training and found employment through Métis Human Resources Development Agreements (MHRDAs). We estimate MHRDA activities’ annual fiscal impact, which includes higher tax revenue,lower government transfers ...
Jean-François Arsenault, Andrew Sharpe
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Residential proximity to transport facilities as urban determinants of individual-level per- and poly-fluoroalkyl substance (PFAS) exposures: Analysis of two longitudinal cohorts in Singapore

Environmental Health
Background Policy-relevant spatial determinants of human exposure to Perfluoroalkyl Substances (PFAS), a broad class of persistent environmental contaminants affecting pregnancy and child development, remain poorly understood because of the diversity of ...
Lucas Shen, Subhashni Raj, Youssef Oulhote, Damaskini Valvi, Sharon Ng, See Ling Loy, Shiao-yng Chan, Tarik Benmarhnia, Jonathan Y. Huang   +8 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Social behavior in ASD males: The interplay between cognitive flexibility, working memory, and functional connectivity deviations

Developmental Cognitive Neuroscience
Autism spectrum disorder (ASD) is highly heterogeneous in presentation. While abnormalities in brain functional connectivity are consistently observed in autistic males, the neurobiological basis underlying the different domains of autism symptoms is ...
Shi Yu Chan, Jasmine Si Min Chuah, Pei Huang, Ai Peng Tan   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source