Results 61 to 70 of about 5,283,554 (314)

Childhood gut microbiome is linked to internalizing symptoms at school age via the functional connectome

Nature Communications
The microbiome-gut-brain-axis plays a critical role in mental health. However, research linking the microbiome to brain function is limited, particularly during development, when tremendous plasticity occurs and many mental health issues, like depression
Francesca R. Querdasi, Jessica P. Uy, Jennifer S. Labus, Jia Xu, Neerja Karnani, Ai Peng Tan, Birit B. F. P. Broekman, Peter D. Gluckman, Yap Seng Chong, Helen Chen, Marielle V. Fortier, Lourdes Mary Daniel, Fabian Yap, Johan G. Eriksson, Shirong Cai, Mary Foong-Fong Chong, Jia Ying Toh, Keith M. Godfrey, Michael J. Meaney, Bridget L. Callaghan   +19 more
doaj   +1 more source

芬蘭教育的變革：新制度論觀點的分析 Book Review: Innovation, Human Capabilities, and Democracy: Towards an Enabling Welfare State

Journal of Curriculum Studies, 2016
自從西元2000 年起， 經濟合作暨發展組織（Organization for Economic Cooperation and Development, OECD）開始舉辦「國際學生評量計畫」（Programme for International Student Assessment, PISA），芬蘭學生的成績便引起全球關注，大 家都想知道：這個人口不到臺灣四分之一的「小國」，為什麼可以獲得「世界第一」？曾志朗看見的是「閱讀文化的深度」，形成芬蘭人既遵傳統又重創新的教育風格 ...
李崗 Lee-Kang
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Impacts of Climate Change on indirect human exposure to pathogens and chemicals from agriculture [PDF]

, 2008
Objective: Climate change is likely to affect the nature of pathogens and chemicals in the environment and their fate and transport. Future risks of pathogens and chemicals could therefore be very different from those of today.
Hardy, Anthony, Levy, Leonard, Richard J. Williams, Boucard, Tatiana, Falloon, Peter D, Peter D. Falloon, Turley, David B, Levy, Leonard S., Gordon Nichols, Wellington, Elizabeth M H, Stone, D, Stone, David, Williams, Richard J., Tatiana Boucard, Boxall, AB, Williams, Richard, Boucard, T, Buelke, Sabine, Parsons, Simon, Boxall, Alistair BA, Wellington, Elizabeth MH, Leonardi, Giovanni, Leonardi, G, Kerry Walsh, Edward Topp, Walsh, Kerry, Boxall, Alistair B. A., Thomas Hutchinson, Parsons, Simon A, Kovats, RS, David Stone, Burgin, Laura, Haygarth, Philip, Wellington, Elizabeth, Parsons, SA, Kovats, R Sari, David B. Turley, Nichols, G, Nichols, Gordon, Falloon, Peter, Haygarth, Philip M, Topp, E, Levy, Leonard S, Haygarth, PM, Anthony Hardy, Hutchinson, T, Leonard S. Levy, Alistair B.A. Boxall, Laura Burgin, Kovats, R. Sari, Giovanni Leonardi, Haygarth, Philip M., Turley, David B., Parsons, Simon A., Beulke, Sabine, Williams, RJ, Wellington, EMH, Elizabeth M.H. Wellington, Beulke, S, Hutchinson, Thomas, Turley, DB, Levy, LS, Potts, L, Falloon, PD, Philip M. Haygarth, Simon A. Parsons, Sabine Beulke, R. Sari Kovats, Boxall, ABA, Boxall, Alistair, Hardy, A, Falloon, Peter D., Wellington, Elizabeth M. H., Potts, Laura, Topp, Edward, Walsh, K, Boxall, Alistair B.A., Boxall, Alistair B A, Kovats, Sari, Turley, David, Burgin, L, Wellington, E. M. H., Laura Potts, Williams, Richard J, Hutchinson, TH   +84 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Self-processes, learning, and enabling human potential

, 2008
Self-processes drive engagement in learning and underpin human potential. These self-processes include self-concept, self-regulation, self-determination, self-efficacy, well-being, resilience, and motivation. These self-processes are dynamic and interact.
Craven, Rhonda, Marsh, Herbert W., McInerney, Dennis M.   +2 more
core  

Core features of positive mental health in adolescents and their protective role against psychopathology

Scientific Reports
Mental health is more than the absence of mental illnesses. However, while we acknowledge the importance of positive mental health, there is a lack of comprehensive understanding about positive mental health in adolescents and how it protects against ...
Desiree Y. Phua, Chermaine S. M. Chew
doaj   +1 more source

The science against sugar, alone, is insufficient in tackling the obesity and type 2 diabetes crises – We must also overcome opposition from vested interests

Journal of Metabolic Health, 2018
No abstract available.
Aseem Malhotra, Grant Schofield, Robert H. Lustig   +2 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source