Results 41 to 50 of about 5,283,554 (314)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
The Key to Peace: Unlocking the human potential in Sudan [PDF]
, 2002 This report, produced by six aid agencies operating in Sudan, articulates the appalling human cost of Sudan's conflict. It calls for urgent and sustained action on the part of warring parties and the international community to bring about an immediate ...
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Sport’s potential in promoting human rights: tennis for gender equality and women’s empowerment
, 2022 reservedOver the last few decades, sport has grown in its importance. Sport has gained much popularity due to its professionalisation, globalisation, freedom of movement, technological progress, media, and marketing.
SLIWINSKA, ADRIANNA MALGORZATA
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Cavity Potentials of the Human Ventricles [PDF]
Circulation, 1951 Intracavitary potentials of the human left ventricle were studied in 8 patients by the technic of retrograde ulnar artery or, in one case, pulmonary vein catheterization. The intracavitary potentials from the left ventricle were of the QS variety and confirm Wilson's concept of the earlier depolarization of the intraventricular septum from left to ...
H A, ZIMMERMAN, H K, HELLERSTEIN
openaire +2 more sources
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Comprehensive PsychiatryBackground: Firefighters are regularly exposed to potentially psychologically traumatic events (PPTEs), significantly increasing their risk of mental ill-health.
Jessica L. Campbell +4 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Aberrance of Zinc Metalloenzymes-Induced Human Diseases and Its Potential Mechanisms
, 2021 Zinc, an essential micronutrient in the human body, is a component in over 300 enzymes and participates in regulating enzymatic activity. Zinc metalloenzymes play a crucial role in physiological processes including antioxidant, anti-inflammatory, and ...
Yunqi Cheng, Hongping Chen
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