Results 51 to 60 of about 5,283,554 (314)

Even moderate liver fat accumulation below conventional fatty liver cutoffs is linked to multiple metabolomic alterations and gestational dysglycemia in Asian women of reproductive age

BMC Medicine
Background It is not clear if conventional liver fat cutoff of 5.56% weight which has been used for identifying fatty liver in western populations is also applicable for Asians.
Priti Mishra, Suresh Anand Sadananthan, Jadegoud Yaligar, Kok Hian Tan, Yap Seng Chong, Peter D. Gluckman, Keith M. Godfrey, Marielle V. Fortier, Johan G. Eriksson, Jerry Kok Yen Chan, Shiao-Yng Chan, Dennis Wang, S. Sendhil Velan, Navin Michael   +13 more
doaj   +1 more source

Determining a diagnostic algorithm for hyperinsulinaemia

Journal of Metabolic Health, 2019
Background: Ascertaining Kraft dynamic insulin response patterns following a 3-h 100 g oral glucose tolerance test seems to be the most reliable method for diagnosing hyperinsulinaemia.
Catherine A.P. Crofts, Grant Schofield, Mark C. Wheldon, Caryn Zinn, Joseph R. Kraft   +4 more
doaj   +1 more source

Proliferative Potential of Human Astrocytes [PDF]

Journal of Neuropathology & Experimental Neurology, 2005
Although a number of studies have demonstrated proliferation of nonneoplastic astrocytes in experimental animal models, the proliferative potential of human astrocytes has not been well defined. Using double-label immunohistochemistry, we identified proliferating cells with the proliferation marker MIB-1 and astrocytes with glial fibrillary acidic ...
Kenneth J, Colodner, Rachel A, Montana, Douglas C, Anthony, Rebecca D, Folkerth, Umberto, De Girolami, Mel B, Feany   +5 more
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

MMP-10 is overexpressed, proteolytically active and a potential target for therapeutic intervention in human lung carcinomas

, 2004
NoMatrix metalloproteinase (MMP)-mediated degradation of the extracellular matrix is a major factor for tumor development and expansion. This study analysed MMP-10 protein expression and activity in human lung tumors of various grade, stage, and type to ...
Tijani, S., Jason H. Gill, Martin, Sandie W., Alan J. Mearns, Alan Anthoney, Mearns, A.J., Kirwan, I.G, Anikin, V.A., Anikin, V.A, Gill, J.H, Tijani, S, Loadman, Paul, Anthoney, A, Jill M. Seargent, Sandie W. Martin, Mearns, Alan J., Kirwan, Ian G., Seargent, Jill M., Anthoney, Alan, Loadman, P.M, Seargent, J.M, Mearns, A.J, Anikin, Vladimir A., Ian G. Kirwan, Tijani, Sidiq, Bibby, M.C, Martin, S.W, Sidiq Tijani, Bibby, Michael C., Loadman, Paul M., Gill, Jason H., Michael C. Bibby, Paul M. Loadman, Vladimir A. Anikin   +33 more
core   +1 more source

Active components in digital health interventions for sleep among adolescents: a systematic review and meta-analysis of randomized controlled trials

npj Digital Medicine
Digital health interventions (DHIs) offer scalable, accessible approaches to promote healthy sleep in adolescents and to prevent or treat poor sleep and insomnia.
A. Salamanca-Sanabria, A. Fogel, N. Padmapriya, C. Meenushree, A. Rodriguez, JG Eriksson   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Online language of violent rioters displayed weak group affiliation preceding the U.S. Capitol Breach

Communications Psychology
The riot that occurred on January 6th, 2021, at the Federal Capitol buildings represented a form of political violence rarely witnessed in the history of the United States.
Ari P. Kirshenbaum, Gideon Cunningham, Lydia Mudd, Michael J. Sofis, James W. Pennebaker   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Conditional immortalization of human B cells by CD40 ligation [PDF]

, 2008
It is generally assumed that human differentiated cells have a limited life-span and proliferation capacity in vivo, and that genetic modifications are a prerequisite for their immortalization in vitro.
Mayr, C., Caroline Zentz, Reinhard Zeidler, Hammerschmidt, W., Wolfgang Hammerschmidt, Wiesner, Martina, Wimmer, Rainer, Wiesner, M., Christine Mayr, Hammerschmidt, Wolfgang, Zentz Caroline, Zentz, C., Moosmann, A., Zeidler, Reinhard, Wiesner Martina, Moosmann Andreas, Andreas Moosmann, Mayr Christine, Wimmer, R., Wimmer Rainer, Zentz, Caroline, Hammerschmidt Wolfgang, Mayr, Christine, Martina Wiesner, Moosmann, Andreas, Rainer Wimmer, Zeidler Reinhard, Zeidler, R.   +27 more
core   +1 more source