Results 121 to 130 of about 1,491,738 (312)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Pressure mapping of medical compression bandages used for venous leg ulcer treatment [PDF]

, 2010
Chronic leg ulcers affect 1% of the adult population in the developed countries. The majority of leg ulcers are due to venous disease. The impact of venous ulcers on the quality of life is significant, and it costs the NHS £300 − 600m annually.
Al Khaburi, Jawad Ameen Jawad
core  

Threshold Responses of Bird Communities to Human Footprint: Testing the Intermediate Disturbance Hypothesis and Implications for Biodiversity Conservation

Ecology and Evolution
Human activities have profoundly altered natural ecosystems, driving widespread biodiversity declines. Birds serve as key environmental health indicators and exhibit high sensitivity to such changes.
Xi Yang, Lishi Zhang, Piotr Tryjanowski, Frédéric Jiguet, Zheng Han, Haitao Wang   +5 more
doaj   +1 more source

Diversity of European habitat types is correlated with geography more than climate and human pressure. [PDF]

Ecol Evol, 2021
Cervellini M, Di Musciano M, Zannini P, Fattorini S, Jiménez-Alfaro B, Agrillo E, Attorre F, Angelini P, Beierkuhnlein C, Casella L, Field R, Fischer JC, Genovesi P, Hoffmann S, Irl SDH, Nascimbene J, Rocchini D, Steinbauer M, Vetaas OR, Chiarucci A.   +19 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Training Pressure Suit Manual

Immediate accessThis item is made available by the University of Arizona Center for Human Space Exploration (CHaSE) with support from the University of Arizona Libraries.
Smith, Cameron M., Tresch, Trent
core  

Influence of probe pressure on human skin diffuse reflectance spectroscopy measurements [PDF]

, 2009
In a routine procedure for collecting human skin spectra using fiber optic diffuse reflectance spectroscopy, the fiber optic probe is put gently in contact with the skin surface.
JORGE CASTRO RAMOS, EBER ENRIQUE OROZCO GUILLEN, MARGARITA CUNILL RODRIGUEZ, SERGIO VAZQUEZ Y MONTIEL, JOSE ALBERTO DELGADO ATENCIO   +4 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Can interface conditions be modified by support surfaces to minimise the risk of pressure ulcer development?

, 2011
PhDThe characteristics of a patient support interface can influence the susceptibility of subjects, particularly there who are immobilised and insensate, to pressure ulcer development.
Chanyuan Chai, Chai, Chanyuan
core  

Genomic signatures of drift and selection driven by predation and human pressure in an insular lizard. [PDF]

Sci Rep, 2021
Bassitta M, Brown RP, Pérez-Cembranos A, Pérez-Mellado V, Castro JA, Picornell A, Ramon C.   +6 more
europepmc   +1 more source