Results 101 to 110 of about 1,491,738 (312)
Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan +11 morewiley +1 more sourceGenetic variants in novel pathways influence blood pressure and cardiovascular disease risk [PDF]
, 2011 Blood pressure is a heritable trait1 influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension ($140mmHg systolic blood pressure or$90mmHg diastolic blood pressure)2. Even small Harst, P. (Pim) van der, Lawrence, Robert W, Sinning, Christoph, Wichmann HE, Preuss, M., Ridker, P.M., Wilensky R, Launer, L, Assimes, Themistocles L., Go, Alan, Heid, I. M., Ingelsson, E., Elosua, R., Fava, C. (Cristiano), Staessen, J.A. (Jan), Kim, HL, Boerwinkle, E., Dong, Y., Prabhakaran, D, van der Schouw, Y.T., Hicks, Andrew A, Ongen, H. (Halit), Palmer, L.J., Langefeld, C.D. (Carl), Hengstenberg, Christian, Wichmann, H. Erich, Kangas, Antti J., Glazer, NL, Shin Cho, Y. (Yoon), Smith, Nicholas, Peters, Annette, Tayo, B. (Bamidele), Young, J. Hunter, Smith, AV, Day, I.N.M., Lathrop, Mark, Steinle, NI, Stančáková, A, Curhan, G. C., Dong, YB, Preuss M, Cooper, Richard S, Glazer, N., Kuznetsova, T, Barroso, Inês, Ong, R.T., Lawrence, Robert W., O´Connell, J.R., Forrester, T, Corsi, A.M. (Anna Maria), Vinay, D G, Chambers, John C, Tomaszewski, M, Palmer, Lyle J., O'Donnell, CJ, Frayling, Timothy M., Nilsson, Peter M., Wichmann, H.E. (Heinz Erich), Floege, J., Seielstad, M, Hwang, S. J., Roberts, Robert, Igl, W., Harris, T.B. (Tamara), Knowles, J., Ongen, Halit, Voelker, Uwe, Quertermous, T., Seielstad, Mark, Heckbert, Susan R., Lee, NR, Miki, T., Johnson, A.D. (Andrew), Li, Mingyao, Nilsson, P. (Peter), Munroe, PB, Kong, A., Ong, RT, Schillert, A., Perret, Claire, Ludwig, Barbara, Thorgeirsson, G., Milaneschi, Y. (Yuri), Smith, GD, Rivadeneira, F, Turner, S. T., Chang, Yen-Pei C, Bilo, H. J., Sidney, Steven, Fava, Cristiano,, Salako, T., Iwai, N., Lackner, K., Strachan, David P., Schreiber, S., Morris, R.W. (Richard), Ohkubo, T, Johnson, T, Ong, RTH, Nelson C, Sinning C, Bolton, J.A.H., Chen L, Wu, Fenny, Rudan, I. (Igor), König, I. R., Winkelmann, B.R., Orru, Marco, Järvelin, M.-R., Najjar, S., Nicaud, Viviane, O’Donnell, Christopher J., Tripathy, Vikal, Uitterlinden, Andre G, Braund, Peter S., van Gilst, WH, Smith, A.V. (Albert Vernon), Quertermous T, Völker, U. (Uwe), Fortmann, Stephen, Knouff, C.W., Zillikens, M. C., Sternberg, M. J., Rice, K.M., Zhang, W., Illig T, Levy, D. (Daniel), Taylor, K.D., Gyllensten, Ulf B, Andersen, K., Mani, K Radha, Milaneschi, Y, Raitakari, Olli T., Vitart, Veronique, Völzke, H. (Henry), Emilsson, V., Hercberg, S., Iribarren, Carlos, Nguyen, Khanh-Dung Hoang, Waterworth, Dawn M., Lucas, Gavin, Cupples, L.A., Kähönen, M., Loley, Christina, Cavalieri, M., Dominiczak, Anna F, Wright, A.F., van der Schouw, YT, Gao, X., Hadley, D., Sijbrands, Eric J.G., Burtt N, Talmud, P.J., Hakonarson, H.H., et al, Kangas, AJ, Gale, D. P., Graessler, J, Wareham, N.J., Scharnagl H, Li, Y., de Faire, Ulf, Longstreth Jr., W.T., Wild, S.H. (Sarah), Heath, S., Weder, A.B. (Alan), Erdmann, Jeanette, Gabriel SB, Zhu, H. (Haidong), Artigas, M.S., Dehghan A, Stancáková, A. (Alena), Illig, T., Soininen, P. (Pasi), Galan, P., Li, YL, Yang, Q., van Gilst, Wiek H, Zhang, WH, Swift, A.J. (Amy), Vineis, P., Hicks, Andrew A., Brand, Stefan Martin, Tai, E Shyong, Jackson, A.U., Knouff, Christopher W., Hoffmann M, Wilson, James F, Whincup, P.H., Wong, TY (Tien Yin), Longstreth Jr, W. T., Org, E, Bornstein, SR, KidneyGen Consortium, Völzke, H, Parker, AN, Wagenknecht, Lynne E., Wass, M. N., Schillert A, Witteman, Jacqueline C.M., Kroemer, H. K., Wu, Y, Hofman A, Guarrera, S, Köttgen, Anna, Chen, I.Y., Dobnig H, Erdmann, J, Adeyemo, A. (Adebowale), Nelson, C., Wright, AF, Boban, M., Larson, Martin G., Najjar, Samer S., Meschia, James F, Farrall, M. (Martin), Hercberg, Serge, Palmer, LJ, Kooner, J.S. (Jaspal), Parker, A. N., Beckmann, Jacques S, Hicks, A.A., Sijbrands, EJ, ICBP Consortium (Meitinger, T. ; Wichmann, H.-E. ; Gieger, C.), Hua Zhao, Jing, Brand, Eva, Waterworth, D., Melander, O, Qu, Liming, Polasek, Ozren, Miki, T, Grässler, J., Medack A, Shriner, D, Chang, Yen-Pei C., Snieder, H. (Harold), Uiterwaal, C.S.P.M., Salomaa, V. (Veikko), van Duijn, Cornelia M., Sehmi, J.S., Zerres, K., Mosley, Thomas H., Kao, WHL, Psaty, B. M., Groop, L. (Leif), Lakatta, Edward G., Ehret, Georg B, Heckbert, S. R., Renner W, Sõber, S. (Siim), Terzic, J. (Janos), Bakker, S.J.L. (Stephan), Jackson, Anne U, Newton-Cheh, C, Ikram, Arfan, Snieder, Harold, Grobbee, D.E. (Diederick), Marciante, Kristin, Struchalin, M., Gabriel, Stacey B., Fowkes, F. Gerald R., Palmas, W, Collins, FS, Lumley, Thomas, Fowkes, F.G.R., Kim, Hyung Lae, Janipalli, C.S., Hernandez, Dena, Zhao, JH, Kumar, M. V. Kranthi, Kuusisto, J. (Johanna), Laakso, M. (Markku), Shrine, N.R., Kivimaki, M., Chen, M.H., Longstreth, W. T., Jr., Chang, Y.-P.C. (Yen-Pei), Langefeld, Carl D., Pramstaller, PP, Hoang Nguyen, KD, Uiterwaal, CSPM, Greiser, K. H., Vollenweider, P, Smith, A., Najjar, S.S. (Samer), Rotimi, C, Halperin, Eran, Coresh, J., Ala-Korpela, M. (Mika), Barroso, I.E. (Inês), Zhu, Haidong, Elliott, P., Fuchsberger, C., Prabhakaran, Dorairaj, Palmas, W., Hilton, Gina, Demissie, Serkalem, Whincup, Peter H., Tanaka, T, Humphries, S.E. (Steve), Cupples LA, Steinle, Nanette I., Hwang, S-J, Psaty, Bruce M., Salako, Tunde, Onland-Moret, N.C. (Charlotte), Jarinova, O., Mägi, R., Vinay, D. G., Beilby, John P, Smith, N.L., Elosua, Roberto, Demirkan, A, Tuomilehto, J., Zhai, G. (Guangju), Swift, Amy J, Galan, P, Köttgen, A., Morrison, Alanna C, Hoffmann, Michael M., Arfan Ikram, M., Uiterwaal, CS, Walker, M.C., Gaunt, Tom R., Deloukas, P, Launer, L. J., Ehret, G.B., Prabhakaran, D., Lakatta, EG, Krämer, B. K., Holm H, Bis, J.C. (Joshua), Franke, A., Cooper, Jackie A., Chasman, D.I. (Daniel), Lieb, W., Mohlke, K.L., Campbell, Harry, Teumer, A. (Alexander), Garcia, Melissa E, Voight, Benjamin F, Lyytikäinen, L.-P., Pichard AD, Scott, J., Ellinghaus, D., Mattace-Raso, Francesco U.S., McKenzie, C.A., Lyytikainen, L-P, Bochud, M., Hlatky M, Bergmann, S, Plump, A., Tang, Hua, Lawrence, RW, Medack, A., Parsa, A., Khaw, KT, Hartikainen, AL, Schnabel R, Talmud, Philippa J., Hoffman Bolton, Judith A., Grosshennig A, Heckbert, Susan, Yajnik, C.S., Charchar, Fadi J., Heckbert, S.R. (Susan), Satler, Lowell, Rotter JI, Hernandez, D.G. (Dena), Erdmann, J. (Jeanette), Chasman, DI, Adeyemo, A, Zhu, H, Smith, G.D., Denniff, M. (Matthew), Absher D, Matthai, W., Doering, Angela, Young, J Hunter, Rao, Dabeeru C., Thompson, J.R., Zelenika, D, Mattace-Raso, Francesco U S, Alexander, Myriam, Zhu, X, Lathrop, G.M. (Mark), Li, M., Langefeld, C.D., Bots, ML (Michiel), Kangas, A.J. (Antti), Bis, J.C., Wilson, J.F., Doumatey, Ayo P., Samani, N.J., Meisinger C, Okamura, Tomonori, Kent, K.M., Kathiresan, S, Rader, Daniel J., Schwartz, S.M. (Stephen), Raitakari, O., Friedrich, N., International Consortium for Blood Pressure Genome-Wide Association Studies, Platou, C. (Carl), Connell, J. M., Samani NJ, Beilby, JP, Palmer, ND, Wong, Tien Y, Knowles, Joshua, Howard, P, Soranzo, N., Adair, LS, Schmidt, H., Epstein, S., Waeber, G., Pouta, A., Rotter, J. I., Perola, M. (Markus), Wichmann, HE, Day, Ian N.M., Preuss, Michael, Brand, E (Eddy), Isaacs, A., Kardia, Sharon L. R., Homan van der Heide, J. J., Chang, Y-PC, Arnett, D. K., Hwang, S.J., Brand, E, Burton, P.R. (Paul), Wilson, James F; id_orcid, Corsi, Anna Maria, O'Reilly, P.F., Bergmann, S., Voelker, U, Völker, U., Rettig, R. (Rainer), Kuh, D, Bickel, Christoph, Frayling, Timothy M, Farrall, M., Teumer, Alexander, Umemura, S., Matullo, G., Dominiczak, Anna F., Demirkan, A. (Ayşe), Wells, G.A., Ehret, Georg B., Laan, M, Emilsson, Valur, Zelenika, D. (Diana), Aulchenko, Yurii S., Cupples, L. Adrienne, Bakker, Stephan J.L., Peden, John F., O’Reilly, Paul F., Lakatta, Edward G, Vasan, RS, Beckmann, J.S. (Jacques), Lawlor, D. A., Loehr, Laura R., Prokopenko, I, Kuznetsova, T. (Tatiana), Chambers, J.C., Khaw, Kay-Tee, Viigimaa, M., Day, I.N., Raffel, Leslie J, Sijbrands, E.J.G. (Eric), Taylor, A., Schlieper, G., van der Schouw, Yvonne T., Ganesh, Santhi K, Samani, Nilesh J, Peltonen, L. (Leena Johanna), Kardia, S.L., Tomaschitz A, Rodeheffer, R. J., McArdle, W.L., Melander, O., Parsa, A. (Afshin), Cooper, J.A., Wong, T.Y., Zitting, P. (Paavo), Sidney, S., Fox, E.R. (Ervin), Gretarsdottir, Solveig, Khanh-Dung Hoang, Nguyen, Hayward, Caroline, Hofman, A. (Albert), Nahrstedt, J., Erdmann J, Ohkubo, T., Voight, B.F., Igl, Wilmar, Steinle, N.I. (Nanette), Wild, S. H., Lackner, K. J., CARDIoGRAM Consortium, Kroemer, H.K., Ala-Korpela, Mika, Caulfield, MJ, Haritunians, T., Coresh, J, Fowkes, FGR, Rasheed, A. (Asif), Balmforth AJ, Schmidt, R., Winkler K, Kooner, JS, McKenzie, Colin A., Hicks, AA, Kuusisto, Johanna, Aspelund, T, Chang, Y.-P.C., Mattace-Raso, FU, Adeyemo, A., Morris, Richard W, Lakatta, E.G., International Consortium for Blood Pressure Genome-Wide Association Studies,, Dreisbach, A.W., Oostra, B.A., Emilsson, V, Watkins, Hugh, Freyer, J., Shi, G. (Gang), Kulkarni, SR, Thelle, Dag S, Morken, Mario A, Fowkes, F.G.R. (Gerald), Jafar, T.H., Ramachandran, Vasan, O'Reilly, P.F. (Paul), Renner, Wilfried, Viigimaa, Margus, Saleheen, Danish, Spector, T.D., Sijbrands, E.J., Loos, R.J.F., Kinra, S, Howard, P., Sjögren, Marketa,, Scott, LJ, Gulde, Stephanie, Kathiresan, Sekar, Rice, Kenneth M, Larson, Martin G, Wilson, JF, Gyllensten, U.B., Han, B.-G., Kardia, S.L. (Sharon), Holm, H., Abecasis, G. R., Lohman, Kurt K., Aulchenko, Yurii, Rupprecht HJ, Arora, P., Bots, Michiel L., Münzel T, Absher, D., Alexander, M. (Myriam), Hwang, Shih Jen, Kulkarni, S.R., Aulchenko, Yuriy, Gaunt, Tom R, Wilson, J.F. (James), Wong, TY, Sõber, Siim, Meitinger, T. (Thomas), Wain, Louise V, Bickel C, Grosshennig, A., Cooper, M.N. (Matthew), Zukowska-Szczechowska, E., Hopewell, J.C., Barbalic M, McPherson, R., Ikram, M.A. (Arfan), Palmen, J., Barroso, Ine S., Lee, JY, Wagenknecht, L.E. (Lynne), Lackner, Karl, Hlatky, M., Vartiainen, E., Uda, M., Danesh, J, Weder, Alan B., Rivadeneira Ramirez, F. (Fernando), Connell, J.M., Linsel-Nitschke, P., Wong, Tien Y., Böhm BO, Harris, Tamara B, Watzinger, N., Morrison, A.C. (Alanna), Kathiresan, S., Okamura, T. (Tomonori), Ong, Rick Twee Hee, Kettunen, Johannes, Bickel, C., Campbell, H. (Harry), Caulfield, M. (Mark), Groop, L, Boehnke, M, Walker M, Wichmann, H.-E., Kathiresan S, Folsom, A., Willenborg, C., Shi, Gang, Knowles J, Chen, Ming Huei, Zhu, H., van Duijn, C. M., Peltonen, L, Humphries, S.E., Kita, Y, Sidney S, Kao, W.H.L., Blankenberg, Stefan, Levy D, Cooper, Matthew N, Zhu, HD, Melander, Olle,, Peden, J. (John), Kumari, M. (Meena), Terzic, J., Whincup, PH, Swift, A.J., Ueshima, H. (Hirotsugu), Thorgeirsson, Gudmundur, Tayo, B., Sehmi, J. S., Demirkan, A., Bochud, Murielle, Doumatey, A, Nalls, Michael A., Humphries, Steve E, Parker, A.N. (Alex), Ebrahim, S., Hveem, K., Longstreth, W T, Kong, Augustine, Taylor KD, Mooser, Vincent, Uitterlinden, AG, Heckbert, Susan R, Orru, M., Gieger, C, Kumar, MV, Pichard, A.D., Harris, Tamara, Laaksonen, R., Levy, Daniel, Wiggins, K.L. (Kerri), Khaw, K-T. (Kay-Tee), Wichmann, H-Erich, Tobin, M.D. (Martin), Burnett, Mary Susan, Cooper, RS, Goel, Anuj, Wong, A., Dockrell, M., Watkins, H., Aspelund, T. (Thor), Thelle, Dag S., Vineis, Paolo, Schlessinger, D., Roberts R, Narisu, N., Lindsay, J.M., Platou, C.G.P., Chang, YPC, Andersen K, Ueshima, Hirotsugu, van Duijn, CM, Lee, J.Y., Nauck, M., Lawrence, R.W. (Robert), Bakker, Stephan J. L.; id_orcid, Langefeld, CD, Bots, Michiel L, Campbell, Harry; id_orcid, Longstreth jr., W. T., Wiggins, K.L., Kuznetsova, Tatiana, Meschia, JF, Ferrucci, L. (Luigi), Chasman, Daniel I, Kumar, M V Kranthi, Kolcic, I., Sõber, S, Singleton, Andrew, Ridker, P. M., Johnson, T., van Duijn, C., Salomaa, V, Sjögren, M, Kinra, S. (Sanjay), Hveem, K. (Kristian), Lumley T, Shuldiner, A.R., McKenzie, CA, Han, BG, Rudock, M.E., Paré, G., Soranzo, N. (Nicole), Seshadri, S., Platou, C.G., Hilton, G., Brown, MJ, Lagou, V., Halperin, E., Vineis, P. (Paolo), Wiggins, Kerri L, Province, M., Uda, Manuela, Ricceri, F. (Fulvio), Prokopenko, Inga, Marciante, K., Parker, Alex N., Harris T, O'Donnell CJ, Ikram, M Arfan, Felix, J. F., Snieder, H, Bergmann, Sven, Lawlor, Debbie A., Launer, Lenore J., Fox, C. S., Bergmann, S.M. (Sven), Wichmann, H. E., Loos, R.J.F. (Ruth), Wareham, N.J. (Nick), Adair, L.S., Hingorani, Aroon D., Rotimi, C. (Charles), Scuteri, A., König IR, Luan, Jian’an, Kleber, Marcus, Dreisbach, Albert W, Ueshima, H., Raffel, L.J. (Leslie), Rotter, Jerome I, Marmot, MG, Badola, S., Kuh, D., Hengstenberg C, Cambien, F., Dikkeschei, L. D., Goel, A., Bornstein, S.R. (Stefan), Thompson, John R., Walker, Max C., Risch N, Kim, H-L, Stojakovic, Tatjana, Hunt, Steven C, Terzic, Janos, Erdmann, J., Arora, Pankaj, Aulchenko, Y. S., Laitinen, J, Wagenknecht, Lynne E, Janipalli, CS, Chambers, J. C., Sjögren, Marketa, Fowkes, F.G., Raffel, L.J., Absher, Devin, van der Harst, Pim, Adeyemo, Adebowale, Perucha, E., Lucas, G. (Gavin), Palmer, Nicholette D., Sun, Yan V, Corsi, A.M., Schwarz, P.E., Tobin, Martin D, Jarinova O, Sun, Yan V., Artigas, Maria Soler, Nguyen, KD, Homuth, G., Maxwell, P. H., Dobnig, H., Onland-Moret, Charlotte N, Gretarsdottir, S., Jafar, T.H. (Tazeen), Uitterlinden, A. G., Sharma, P. (Pankaj), Mooser, V. (Vincent), Shaw-Hawkins, S. (Sue), Loley C, Koettgen, A, Guarrera, Simonetta, Wain, L.V. (Louise), Beckmann, J.S., Zgaga, L., Bolton, Judith A Hoffman, Stenvinkel, P., Kinra, Sanjay, Chambers, John C., Dahgam, S, Polasek, O., Lohman, Kurt K, Würtz, P., Kullo, I., Uitterlinden, A., Kumar, MV Kranthi, Brand, S-M, Kita, Yoshikuni, Morrison, Alanna, Collins, Francis S., Schunkert H, Iwai, N, Nalls, Michael A, Harris, TB, Wu, Y., Casas, Juan P., Deloukas, Panos, Pilz S, Ohkubo, Takayoshi, Harris, T., Shrine, Nick RG, Wareham, Nicholas J., Dahgam, S. (Santosh), O'Connell, J.R., Sim, X. (Xueling), Saleheen, D., Stewart, A.F., Arking, Dan E., Laitinen, Jaana, Brand, S.-M., Bakker, S. J., Abecasis, GR, Oostra, B.A. (Ben), Wang, TJ, Maria Corsi, Anna, Go, Min Jin, Kardia, Sharon L., Burtt, Noel, Ludwig, B, Zhao, J.H., Cooper, Jackie A, Vitart, V, Larson, M.G., Shaw-Hawkins, S, Fortmann S, Hayward, C, Waterworth DM, Mattace-Raso, F.U., Chen IY, Wang, X., Seelen, M. A., Gyllensten, U. (Ulf), Strachan, DP, Vasan, R.S., Böhm, Bernhard O., Lakatta, E. (Edward), Glazer, N.L., Kettunen, J, Cooper, R.S., Bornstein, Stefan R., Spector, TD, Vineis, P, Taylor, A. (Andrew), Tang, H., Wang, W., Tukiainen, Taru, Sehmi, Joban S., Milaneschi, Y., Wichmann, H. -Erich, Ferrucci, L., Nelson, Chris, Connell, JM, Hartikainen, A.L., Oostra, B. A., Hveem, Kristian, Bis, J. C., Forrester, T. (Terrence), Dahgam, Santosh, Munzel, T. F., Raffel, Leslie J., Denniff, Matthew, Lee, N.R. (Nanette), Isaacs, A, Zhu, XF, Tabara, Y, Peden, JF, Uda, M. (Manuela), Lehtimäki, T, Sim, Xueling, Strachan, David P, Shi, G., Mitchell, G. F., Tiret L, Guarrera, S., Abecasis, G.R. (Gonçalo), Winkler, Karl, Vasan, R. S., Spector, T. D., Radha Mani, K., Altshuler D, Samani, Nilesh J., Platou, CGP, Campbell, H, Bakker, Stephan J. L., Marciante K, Hofman, Bert, Wright, A. F., Nguyen, K.D., Gulcher, Jeffrey R., Burton, Paul R., Hunt, SC, Hercberg, S. (Serge), Watkins, H, Chang, YP, Bolton, Judith A. Hoffman, Ferrucci, Luigi, Zhu, X., Kardia, Sharon L, Kumar, M.V., Pichard, Augusto D., Spector, Tim D., Olden, M, Sijbrands, Eric J G, Olden, M., Gansevoort, R. T., Snieder, H., Wang, Xiaoling, Nitsch, D., Nicaud V, Arking, D.E. (Dan), Day, IN, Wichmann, H.-Erich, Shriner, D. (Daniel), Kleber M, Gaunt, TR, Ricceri, F., Khaw, K-T, Stark, K., Charlotte Onland-Moret, N., Meneton, Pierre, Khaw, K.-T., Smith, N. L., Hakonarson, Hakon H., Würtz, Peter, Gieger, C., Umemura, S. (Satoshi), Kleber, M., Pihur, Vasyl, Verwoert, G.C. (Germaine), Ridker, Paul M, Artigas, MS, Redfield, M. M., Lyytikäinen, LP, Elliott, P. (Paul), O'Donnell, Christopher J., Jarvelin, M-R, Wild, Philipp, Rice, K.M. (Kenneth), Lawlor, DA, Altshuler, D, Clarke, Robert, Miki, Tetsuro, Seielstad, M. (Mark), Hartikainen, Anna Liisa, Chambers, JC, Coresh, J. (Josef), Waterworth, D.M., Olden, M. (Matthias), Mangino, Massimo, Hicks, A.A. (Andrew), Verwoert, Germaine, Lucas, G, Hadley, D, Wild, S.H., Miki, T. (Tetsuro), Palmas, W. (Walter), Clarke, R., Rudock, Megan E., Sim, X, Fava, Cristiano, de Andrade, M., Mosley, TH, Swaminathan, R., Werdan, K., Hamsten, A. (Anders), Zhai, Guangju, Stefansson, K., Eiriksdottir, G., Würtz, P, Tiret, L., Johnson, AD, Siscovick, D., Wilde, S. +999 morecore +1 more sourceEngineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang +12 morewiley +1 more sourceKeratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer +13 morewiley +1 more sourceResearch on Normal Human Plantar Pressure Test
MATEC Web of Conferences, 2016 FSR400 pressure sensor, nRF905 wireless transceiver and MSP40 SCM are used to design the insole pressure collection system, LabVIEW is used to make HMI of data acquisition, collecting a certain amount of normal human foot pressure data, statistical ...Liu Xi Yang, Gao Ren Jie, Feng Si Ling, Chen Xian Mei, Zhao Yao Chi +4 moredoaj +1 more sourceSomatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen +5 morewiley +1 more sourceHigh exposure of global tree diversity to human pressure. [PDF]
Proc Natl Acad Sci U S A, 2022 Guo WY, Serra-Diaz JM, Schrodt F, Eiserhardt WL, Maitner BS, Merow C, Violle C, Anand M, Belluau M, Bruun HH, Byun C, Catford JA, Cerabolini BEL, Chacón-Madrigal E, Ciccarelli D, Cornelissen JHC, Dang-Le AT, de Frutos A, Dias AS, Giroldo AB, Guo K, Gutiérrez AG, Hattingh W, He T, Hietz P, Hough-Snee N, Jansen S, Kattge J, Klein T, Komac B, Kraft NJB, Kramer K, Lavorel S, Lusk CH, Martin AR, Mencuccini M, Michaletz ST, Minden V, Mori AS, Niinemets Ü, Onoda Y, Peñuelas J, Pillar VD, Pisek J, Robroek BJM, Schamp B, Slot M, Sosinski ÊE, Soudzilovskaia NA, Thiffault N, van Bodegom P, van der Plas F, Wright IJ, Xu WB, Zheng J, Enquist BJ, Svenning JC. +56 moreeuropepmc +1 more sourceHippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà +11 morewiley +1 more source
