Results 81 to 90 of about 1,395,647 (265)

Long-Term Forest Landscape Transformation and Registered Forest Crimes in the Eastern Black Sea, Türkiye

Land
Long-term forest landscape change in mountainous rural areas reflects interactions among land-use pressure, forest structure and human activities. This study had two primary objectives: (i) to quantify 53 years of change in forest extent, stand structure
Emre Küçükbekir, Abdullah Yıldız, Uzay Karahalil, Mahmut Muhammet Bayramoglu   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Salt, Blood Pressure, and Human Health [PDF]

Hypertension, 2000
Abstract —The positive relation of sodium intake and blood pressure, first recognized a century ago, has been well established in ecological, epidemiological, and experimental human studies. Equally well established is the association of increasing blood pressure and cardiovascular morbidity and mortality.
openaire   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Endocannabinoids, Blood Pressure and the Human Heart [PDF]

Journal of Neuroendocrinology, 2008
The effects of exogenous and endogenous cannabinoids on the cardiovascular system have been the focus of extensive research. The direct and indirect effects of cannabinoids on heart and blood vessels depend upon experimental conditions, animal species, and, in humans, clinical background.
openaire   +2 more sources

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

P3.25 THE EFFECT OF DIASTOLIC ASYMPTOTIC PRESSURE ON THE RESERVOIR PRESSURE IN HUMAN

Artery Research, 2013
Background: Arterial diastolic asymptotic pressure (P∞) is the pressure reached when the heart stops beating. Determination of the reservoir pressure (Pr) requires a value of P∞ which was previously assumed (1), calculated (2) and measured (3, 4) as 0 ...
A. Borlotti, S. Vermeersch, E.R. Rietzschel, P. Segers, A.W. Khir   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

High exposure of global tree diversity to human pressure. [PDF]

Proc Natl Acad Sci U S A, 2022
Guo WY, Serra-Diaz JM, Schrodt F, Eiserhardt WL, Maitner BS, Merow C, Violle C, Anand M, Belluau M, Bruun HH, Byun C, Catford JA, Cerabolini BEL, Chacón-Madrigal E, Ciccarelli D, Cornelissen JHC, Dang-Le AT, de Frutos A, Dias AS, Giroldo AB, Guo K, Gutiérrez AG, Hattingh W, He T, Hietz P, Hough-Snee N, Jansen S, Kattge J, Klein T, Komac B, Kraft NJB, Kramer K, Lavorel S, Lusk CH, Martin AR, Mencuccini M, Michaletz ST, Minden V, Mori AS, Niinemets Ü, Onoda Y, Peñuelas J, Pillar VD, Pisek J, Robroek BJM, Schamp B, Slot M, Sosinski ÊE, Soudzilovskaia NA, Thiffault N, van Bodegom P, van der Plas F, Wright IJ, Xu WB, Zheng J, Enquist BJ, Svenning JC.   +56 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source