Results 51 to 60 of about 1,395,647 (265)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Les forêts sacrées de l’aire Ouatchi au sud-est du Togo et les contraintes actuelles des modes de gestion locale des ressources forestières

VertigO, 2005
This study was achieved in relict sacred forests, which are very important for their role as a safeguard of biodiversity in the human-populated region of southeast of Togo.
Kokou Kouami, Adjossou Kossi, Hamberger Klaus   +2 more
doaj   +1 more source

The association of disproportionately enlarged subarachnoid space hydrocephalus with cognitive deficit in a general population: the Ohasama study

Scientific Reports, 2021
Disproportionately enlarged subarachnoid space hydrocephalus (DESH) is the characteristic feature of idiopathic normal pressure hydrocephalus. We aimed to characterize the prevalence, development, and association of DESH to cognitive deficit in a large ...
Tomofumi Nishikawa, Ichiro Akiguchi, Michihiro Satoh, Azusa Hara, Mikio Hirano, Aya Hosokawa, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Kyoko Nomura, Atsushi Hozawa, Naomi Miyamatsu, Yutaka Imai, Takayoshi Ohkubo   +13 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Urgent Conservation Actions Are Needed for Qinling Lenok Brachymystax lenok tsinlingensis Li, 1966: Enlightenment From Model Simulations

Ecology and Evolution
The Qinling lenok Brachymystax lenok tsinlingensis Li, 1966, an endemic to China and South Korea, is a rare protected species. Its unique requirements to habitat have made this fish extraordinarily fragile when faced with human pressures and global ...
Yuebing Zhou, Xianghong Dong, Tao Ju, Lei Gan, Zhenlu Wang, Yuxi Lian, Peng Zhang, Xiongfeng Bai, Qing Liu, Shuhai Zhang, Jiyuan Liu, Tao Xiang, Lei Shi, Haibo Jiang, Jian Shao, Miao An   +15 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Numerical Simulation Analysis on Human Pressure During the Accident of Burying People in the Grain Silo Based on DEM

Liang you shipin ke-ji
The analysis of human force conditions in grain silo burial accidents is of great significance for emergency rescue and the development of protective devices.
HE Xiao-wei, CUI Peng-cheng, ZHANG Tao, CHEN Xin   +3 more
doaj   +1 more source

HUMAN PRESSURE AND DAMAGE TO LANDSCAPE

Sustainable Mediterranean Construction
For introducing the subject of human pressure on landscape damages, the paper deals with various issues resulting in a specific path towards the demonstration of an idea: that beauty, sustainability and respect for anthropic as well as natural milieu could provide improvement to landscape quality.
openaire   +2 more sources