Results 41 to 50 of about 1,083,262 (314)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Can Leaders Prevent Technology From Backfiring? Empowering Leadership as a Double-Edged Sword for Technostress in Care

Frontiers in Psychology, 2021
Purpose: Recent studies have called for more contextual studies of technostress and the role leaders can have in this experience. While technostress is an increasingly prevalent and severe phenomenon in care professions, limited studies have addressed ...
Robin Bauwens, Marith Denissen, Jeske Van Beurden, Martine Coun   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Why not a women-to-women mentoring dyad? A grounded theory approach to address inquisitiveness [PDF]

European Journal of Management Studies
PurposeThis study explores the under-researched gender gap in mentoring within the hospitality industry, focusing specifically on female mentees’ experiences and challenges in forming female-to-female mentoring relationships.Design/methodology/approachA ...
Alisha Rath, Lalatendu Kesari Jena, Munmun Goswami, Suchitra Pal   +3 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Does organisational commitment enhance the relationship between job involvement and in-role performance?

SA Journal of Human Resource Management, 2012
Orientation: Job involvement is essential for the performance of employees. Prior researchers have found a weak relationship between job involvement and job performance, but dimensions of commitment have been considered as a mediator to enhance the ...
Talat Islam, Saif Ur Rehman Khan, Ungku N.U. Ahmad, Ishfaq Ahmed   +3 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Mental health of students amidst the COVID-19 pandemic: An empirical study

Heliyon, 2022
Purpose: Considering the severity of the global outbreak of coronavirus (COVID-19) on the whole of humanity, particularly in this case on the physical and mental health of students, this study strives to explore the role of financial worries, employment ...
Md. Ashraful Alam, Ahmed Ishmum Uddin, Md. Aftab Uddin, Salma Begum, Habibun Nahar, Tarik Raihan, Abdul Gaffar Khan   +6 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Green Training and Development Practices on Environmental Sustainability: Evidence from Wamco PLC

Journal of Interdisciplinary Socio Economic and Community Study, 2022
Green training and development practices have been acknowledged as veritable tools for addressing environmental challenges; it is also a key ingredient for promoting the acceptance of environmental conservation in the workplace because in the long run ...
Tinuke Moradeke Fapohunda, Kabiru Ishola Genty, Lateef Okikiola Olanipekun   +2 more
doaj   +1 more source