Results 51 to 60 of about 4,810,442 (265)

The influence of global intellectualization on human development [PDF]

open access: yes, 2019
In the context of the global intellectualization, human capital is the determining factor in the innovation development and the international competitiveness of countries. In the XXI century.
S. Sardak, A. Samoilenko, Sardak, Sergii
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Human Resource Development for State Universities in the Mimaropa Region: Basis for a Model in Preparation for Internationalization

open access: yesDiversitas Journal
This paper undertakes a comprehensive analysis and investigation into the Human Resource Development (HRD) programs implemented by state universities in the MIMAROPA region, with the overarching objective of formulating an international framework model ...
Dante Ariñez
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Human Resources, Poverty, and Regional Development [PDF]

open access: yes
Human development has moved to centre stage in development theory. Education makes an important contribution to economic growth, but achievement of mass education is important for a number of other reasons as well.
Gavin W. Jones
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

RETRACTED: Conceptual Paper

open access: yesSAGE Open, 2012
“Conceptual Paper: Organizational Learning and Its Practices” by Mayuk Dasgupta, SAGE Open , February 1, 2012, DOI: 10.1177 ...
Mayuk Dasgupta
doaj   +1 more source

Profit Sharing in Multinational Corporations

open access: yesSouth African Journal of Business Management, 1975
Multinational corporations are proliferating through­out the world. They are coming not only from the United States, but from Europe and Asia as well. The purpose of this article is to build a case around which is based the concept that profit sharing ...
Charles W. Eisemann
doaj   +1 more source

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