Results 71 to 80 of about 4,810,442 (265)

Human Resources Development Based On Competence [PDF]

open access: yes, 2011
Tulisan ini mencoba memberikan kerangka untuk manajemen sumber daya manusia pada berbagai bentuk organisasi yang akan kita hadapi di masa depan. Arti penting dari manajemen sumber daya manusia dalam dekade mendatang mendorong kita untuk menemukan solusi ...
Jihad, M. Z. (M)
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

The design and development of a social science data warehouse: A case study of the Human Resources Development Data Warehouse Project of the Human Sciences Research Council, South Africa

open access: yesData Science Journal, 2003
This article focuses on the development of a data warehouse to facilitate government decision-making on national human resources development and to provide public access to information.
Andrew Paterson
doaj   +1 more source

DEVELOPING STEP BY STEP AN ONTOLOGY TO SUPPORT HUMAN RESOURCE MANAGEMENT [PDF]

open access: yes
Human Resources Management is aimed at ensuring all activities, development, motivation and retention of human resources within the organization to achieve its objectives with maximum efficiency and meet the needs of employees.
Anamaria SZEKELY
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

The Challenges of Strategic Human Resources Management in Southeast Asian Universities [PDF]

open access: yes, 2018
Nowadays the Higher Education Institutions face major challenges in its development. Demanding from different actors and the orientation of the research, more oriented to innovation and value creation, request news capacities to answer to that. Southeast
Jorge, F., Saraiva, M., Silva, P.
core  

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