Results 51 to 60 of about 5,959,845 (295)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Leadership styles in nursing management: implications for staff outcomes

open access: yesJournal of Health Sciences, 2016
Introduction: Nursing is a people-centred profession and therefore the issue of leadership is crucial for success. Nurse managers’ leadership styles are believed to be important determinant of nurses’ job satisfaction and retention.
James Avoka Asamani   +2 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Approach to Human Resources Performance Measurement

open access: yesLittera Scripta, 2013
The following paper is focused on employee’s performance measurement. The aim of this paper is to realize an expert resources search in the frame of this issue.
Radim Maňák
doaj  

Formation of Human Resources in the Personnel Management System of the Enterprise [PDF]

open access: yesProblemi Ekonomiki
Economic instability, aggravation of social problems, uncertainty of economic guidelines for the development of Ukraine indicate the need to revise the problems and prospects for the development of economic science and practice. The aim of the article is
Khaustova Viktoriia Ye.   +1 more
doaj   +1 more source

The Contemporary Human Resources Function [PDF]

open access: yes, 2017
Current companies encounter important challenges day to day. Many factors such as the economic globalization, the change in the way of working, the Internet boom, and the importance that the service sector is experiencing nowadays influence the new ...
Bryan-Jiménez, Carlos   +1 more
core  

Microeconomic institutions and personnel economics for health care delivery: a formal exploration of what matters to health workers in Rwanda [PDF]

open access: yes, 2018
Background: Most developing countries face important challenges regarding the quality of health care and there is a growing consensus that health workers play a key role in this process.
A Kalk   +30 more
core   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

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