Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Decision-based genetic algorithms for solving multi-period project scheduling with dynamically experienced workforce [PDF]
, 2012 The importance of the flexibility of resources increased rapidly with the turbulent changes in the industrial context, to meet the customers’ requirements.
Attia, El-Awady +2 more
core +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Las Prácticas de Alto Rendimiento en Recursos Humanos: el Caso Español
Tec Empresarial, 2013 La presente investigación tiene como objetivoprioritario ahondar en el conocimiento sobre la tipologíae intensidad del uso en las empresas españolas de lasdenominadas Prácticas de Alto Rendimiento de recursoshumanos.
Roberto Luna Arocas +1 more
doaj
Volunteering Reinvented: Human Capital Solutions for the Nonprofit Sector [PDF]
, 2007 To grow and adapt in today's continuously changing society, a nonprofit organization must recognize the value and contribution of both its paid staff and volunteers.
core
Evidence for more cost-effective surveillance options for bovine spongiform encephalopathy (bse) and scrapie in Great Britain [PDF]
, 2017 Transmissible spongiform encephalopathies (TSEs) are an important public health concern. Since the emergence of bovine spongiform encephalopathy (BSE) during the 1980s and its link with human Creutzfeldt- Jakob disease, active surveillance has been a key
Arnold +16 more
core +3 more sources
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
An integrated national strategy for resource and environmental management in post-apartheid Namibia : a thesis presented in partial fulfilment of the requirements for the degree of Master of Philosophy in Development Studies at Massey University [PDF]
, 1995 This thesis presents a structure for integrated strategic planning across levels of government in Namibia. The study advocates necessary preconditions for the preparation of An Integrated National Strategy for Resource and Environmental Management in ...
Sikabongo, Frederick Mupoti
core
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
The elaboration of the strategic plan regarding human resources [PDF]
The elaboration of the plan constitutes a necessity for an organization which is governed by the desire to maintain the same objectives, that led to remarkable results; the factors’ generalization which influences positively the present situation of the ...
Cristina Maria Stoica
core