Results 1 to 10 of about 106,326,746 (123)

Structural basis for potent neutralization of human respirovirus type 3 by protective single-domain camelid antibodies

Nature Communications
Respirovirus 3 is a leading cause of severe acute respiratory infections in vulnerable human populations. Entry into host cells is facilitated by the attachment glycoprotein and the fusion glycoprotein (F).
Nicole V. Johnson, Revina C. van Scherpenzeel, Mark J. G. Bakkers, Ajit R. Ramamohan, Daan van Overveld, Lam Le, Johannes P. M. Langedijk, Joost A. Kolkman, Jason S. McLellan   +8 more
doaj   +5 more sources

Molecular Evolution of the Fusion Protein (F) Gene in Human Respirovirus 3. [PDF]

Front Microbiol, 2019
To elucidate the evolution of human respirovirus 3 (HRV3), we performed detailed genetic analyses of the F gene (full-length) detected from hundreds of HRV3 strains obtained from various geographic regions.
Aso J, Kimura H, Ishii H, Saraya T, Kurai D, Matsushima Y, Nagasawa K, Ryo A, Takizawa H.   +8 more
europepmc   +5 more sources

Identification of β4GALNT2 as an anti-hPIV3 factor through genome-wide CRISPR/Cas9 library screening. [PDF]

Emerg Microbes Infect
Human respirovirus 3 (also known as human parainfluenza virus 3; hPIV3) is a major cause of severe acute respiratory infections in vulnerable populations.
Wu X, Luteijn RD, Lozano-Andrés E, Marougka K, Li W, Narimatsu Y, van Kuppeveld FJM, Bosch BJ, Lebbink RJ, Vries E, de Haan CAM.   +10 more
europepmc   +5 more sources

Simultaneous outbreaks of respiratory disease in wild chimpanzees caused by distinct viruses of human origin

Emerging Microbes and Infections, 2019
Respiratory viruses of human origin infect wild apes across Africa, sometimes lethally. Here we report simultaneous outbreaks of two distinct human respiratory viruses, human metapneumovirus (MPV; Pneumoviridae: Metapneumovirus) and human respirovirus 3 (
Jacob D. Negrey, Rachna B. Reddy, Erik J. Scully, Sarah Phillips-Garcia, Leah A. Owens, Kevin E. Langergraber, John C. Mitani, Melissa Emery Thompson, Richard W. Wrangham, Martin N. Muller, Emily Otali, Zarin Machanda, David Hyeroba, Kristine A. Grindle, Tressa E. Pappas, Ann C. Palmenberg, James E. Gern, Tony L. Goldberg   +17 more
doaj   +2 more sources

Human parainfluenza virus 3 fusion protein cleavage: a key determinant of infection and spread. [PDF]

J Virol
Human parainfluenza virus 3 (HPIV3) entry into target cells depends on a viral fusion complex composed of hemagglutinin-neuraminidase (HN) and fusion protein (F).
Stearns K, Marcink T, Pawlack E, Sobolik EB, Porotto M, Greninger AL, Nieweisk S, Moscona A.   +7 more
europepmc   +2 more sources

Characterization of viral pathogens associated with symptomatic upper respiratory tract infection in adults during a low COVID-19 transmission period [PDF]

PeerJ, 2023
Background The epidemiology of respiratory tract infections (RTI) has dramatically changed over the course of the COVID-19 pandemic. A major effort in the clinical management of RTI has been directed toward diagnosing COVID-19, while the causes of other,
Nurlan Sandybayev, Vyacheslav Beloussov, Vitaliy Strochkov, Maxim Solomadin, Joanna Granica, Sergey Yegorov   +5 more
doaj   +2 more sources

The active lung microbiota landscape of COVID-19 patients through the metatranscriptome data analysis [PDF]

BioImpacts, 2022
Introduction: With the outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the interaction between the host and SARS-CoV-2 was widely studied. However, it is unclear whether and how SARS-
Yang Han, Zhilong Jia, Jinlong Shi, Weidong Wang, Kunlun He   +4 more
doaj   +1 more source

Divergent Viruses Discovered in Swine Alter the Understanding of Evolutionary History and Genetic Diversity of the Respirovirus Genus and Related Porcine Parainfluenza Viruses

Microbiology Spectrum, 2022
Paramyxoviridae is a rapidly growing family of viruses, whose potential for cross-species transmission makes it difficult to predict the harm of newly emerging viruses to humans and animals. To better understand their diversity, evolutionary history, and
Jin Zhao, Jiumeng Sun, Xinxin Li, Gang Xing, Yifang Zhang, Alexander Lai, Guy Baele, Xiang Ji, Shuo Su   +8 more
doaj   +1 more source

Human parainfluenza virus surveillance in pediatric patients with lower respiratory tract infections: a special view of parainfluenza type 4

Jornal de Pediatria (Versão em Português), 2018
Objective: Characterize the role of human parainfluenza virus and its clinical features in Brazilian children under 2 years of age presenting with acute lower respiratory tract infections.
Luciano M. Thomazelli, Danielle B.L. de Oliveira, Giuliana S. Durigon, Brett Whitaker, Shifaq Kamili, Eitan N. Berezin, Edison L. Durigon   +6 more
doaj   +3 more sources

Detection of porcine parainfluenza virus type-1 antibody in swine serum using whole-virus ELISA, indirect fluorescence antibody and virus neutralizing assays

BMC Veterinary Research, 2022
Background Porcine parainfluenza virus 1 (PPIV-1) is a respiratory virus in the family Paramyxoviridae and genus Respirovirus. It is closely related to bovine parainfluenza virus 3, human parainfluenza virus 1, and Sendai virus.
Michael Welch, Karen Krueger, Jianqiang Zhang, Pablo Piñeyro, Ronaldo Magtoto, Chong Wang, Luis Giménez-Lirola, Erin Strait, Mark Mogler, Phillip Gauger   +9 more
doaj   +1 more source