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Molecular Evolution of the Fusion Protein (F) Gene in Human Respirovirus 3 [PDF]

Frontiers in Microbiology, 2020
To elucidate the evolution of human respirovirus 3 (HRV3), we performed detailed genetic analyses of the F gene (full-length) detected from hundreds of HRV3 strains obtained from various geographic regions.
Jumpei Aso, Hirokazu Kimura, Hirokazu Kimura, Haruyuki Ishii, Takeshi Saraya, Daisuke Kurai, Yuki Matsushima, Koo Nagasawa, Akihide Ryo, Hajime Takizawa   +9 more
doaj   +7 more sources

Molecular evolution of the hemagglutinin-neuraminidase (HN) gene in human respirovirus 3

Virus Research, 2020
Human respirovirus 3 (HRV3) is a major causative agent of acute respiratory infections in humans. HRV3 can manifest as a recurrent infection, although exactly how is not known. In the present study, we conducted detailed molecular evolutionary analyses of the major antigen-coding hemagglutinin-neuraminidase (HN) gene of this virus detected/isolated in ...
Jumpei Aso, Haruyuki Ishii, Takeshi Saraya   +2 more
exaly   +5 more sources

Genetic diversity and evolutionary analysis of human respirovirus type 3 strains isolated in Kenya using complete hemagglutinin-neuraminidase (HN) gene.

PLoS ONE, 2020
Human respirovirus type 3 (HRV3) is a leading etiology of lower respiratory tract infections in young children and ranks only second to the human respiratory syncytial virus (HRSV).
Juliet Elusah, Wallace Dimbuson Bulimo, Silvanos Mukunzi Opanda, Samwel Lifumo Symekher, Fred Wamunyokoli   +4 more
doaj   +4 more sources

Structural basis for potent neutralization of human respirovirus type 3 by protective single-domain camelid antibodies

Nature Communications
Respirovirus 3 is a leading cause of severe acute respiratory infections in vulnerable human populations. Entry into host cells is facilitated by the attachment glycoprotein and the fusion glycoprotein (F).
Nicole V. Johnson, Revina C. van Scherpenzeel, Mark J. G. Bakkers, Ajit R. Ramamohan, Daan van Overveld, Lam Le, Johannes P. M. Langedijk, Joost A. Kolkman, Jason S. McLellan   +8 more
doaj   +3 more sources

Identification of β4GALNT2 as an anti-hPIV3 factor through genome-wide CRISPR/Cas9 library screening [PDF]

Emerging Microbes and Infections
Human respirovirus 3 (also known as human parainfluenza virus 3; hPIV3) is a major cause of severe acute respiratory infections in vulnerable populations.
Xuesheng Wu, Rutger D. Luteijn, Estefanía Lozano-Andrés, Katherine Marougka, Wentao Li, Yoshiki Narimatsu, Frank J. M. van Kuppeveld, Berend Jan Bosch, Robert Jan Lebbink, Erik de Vries, Cornelis A. M. de Haan   +10 more
doaj   +2 more sources

Human parainfluenza virus 3 fusion protein cleavage: a key determinant of infection and spread [PDF]

Journal of Virology
Human parainfluenza virus 3 (HPIV3) entry into target cells depends on a viral fusion complex composed of hemagglutinin-neuraminidase (HN) and fusion protein (F).
Kyle Stearns, Tara Marcink, Emily Pawlack, Elizabeth B. Sobolik, Matteo Porotto, Alexander L. Greninger, Stefan Nieweisk, Anne Moscona   +7 more
doaj   +2 more sources

Characterization of viral pathogens associated with symptomatic upper respiratory tract infection in adults during a low COVID-19 transmission period [PDF]

PeerJ, 2023
Background The epidemiology of respiratory tract infections (RTI) has dramatically changed over the course of the COVID-19 pandemic. A major effort in the clinical management of RTI has been directed toward diagnosing COVID-19, while the causes of other,
Nurlan Sandybayev, Vyacheslav Beloussov, Vitaliy Strochkov, Maxim Solomadin, Joanna Granica, Sergey Yegorov   +5 more
doaj   +2 more sources

The active lung microbiota landscape of COVID-19 patients through the metatranscriptome data analysis [PDF]

BioImpacts, 2022
Introduction: With the outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the interaction between the host and SARS-CoV-2 was widely studied. However, it is unclear whether and how SARS-
Yang Han, Zhilong Jia, Jinlong Shi, Weidong Wang, Kunlun He   +4 more
doaj   +1 more source

Divergent Viruses Discovered in Swine Alter the Understanding of Evolutionary History and Genetic Diversity of the Respirovirus Genus and Related Porcine Parainfluenza Viruses

Microbiology Spectrum, 2022
Paramyxoviridae is a rapidly growing family of viruses, whose potential for cross-species transmission makes it difficult to predict the harm of newly emerging viruses to humans and animals. To better understand their diversity, evolutionary history, and
Jin Zhao, Jiumeng Sun, Xinxin Li, Gang Xing, Yifang Zhang, Alexander Lai, Guy Baele, Xiang Ji, Shuo Su   +8 more
doaj   +1 more source

Human parainfluenza virus surveillance in pediatric patients with lower respiratory tract infections: a special view of parainfluenza type 4

Jornal de Pediatria (Versão em Português), 2018
Objective: Characterize the role of human parainfluenza virus and its clinical features in Brazilian children under 2 years of age presenting with acute lower respiratory tract infections.
Luciano M. Thomazelli, Danielle B.L. de Oliveira, Giuliana S. Durigon, Brett Whitaker, Shifaq Kamili, Eitan N. Berezin, Edison L. Durigon   +6 more
doaj   +3 more sources