Results 121 to 130 of about 9,596,602 (303)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

[Hitler, McCarthy, Anita - Act Now for Human Rights Poster]

Poster advertising the Breakfast Festival for Human Rights at Auditorium Shores. The poster features a black white and red graphic of Anita Bryant's head mid-speech. On the right is printed "Hitler - McCarthy - Anita".

core  

EPIDEMIOLOGICAL RISK OF INTRODUCTION OF DANGEROUS AND EXOTIC INFECTIOUS DISEASES ON THE TERRITORY OF THE XXII OLYMPIC WINTER GAMES AND XI PARALYMPIC WINTER GAMES 2014 IN SOCHI

Журнал микробиологии, эпидемиологии и иммунобиологии, 2015
To assess the epidemiological risk of introduction of serious infectious diseases in the pre-Olympic period defined list of dangerous and exotic infections and held assessment ofpotential danger threatening.
B. P Kuzkin, E. B Ezhlova, A. N Kulichenko, O. V Maletskaya, Yu. V Demina, T. V Taran, N. D Pakskina, T. V Kharchenko, G. M Grizhebovsky, V. N Savelev, V. G Oroby, V. P Klindukhov, T. V Grechanaya, S. Ch Tesheva, G. D Bryukhanova   +14 more
doaj  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

[Breakfast Festival for Human Rights Flyer]

Flyer advertising the Breakfast Festival for Human Rights in response to Anita Bryant's presence in Austin, Texas. The flyer states the festival is "A gathering of all the people of Austin who - by our presence - wish to affirm human rights and ...

core  

Interrogating the role of sociopolitical determinants of health in Palestine: A qualitative study with key informants

Global Public Health
For decades, Palestinians have faced significant barriers to developing and accessing basic health services, leading to poor health outcomes. These issues are often characterized as mere ‘humanitarian issues,’ ignoring the broader sociopolitical context.
Yara M. Asi, David Mills, Nicole B. Alkhouri, Rasha Kaloti, Nadine Bahour, Osama Tanous, Bram Wispelwey, Weeam Hammoudeh   +7 more
doaj   +1 more source

Human Rights and Human Nature

Tópicos, Revista de Filosofía, 2013
Parece que hay dos diferentes versiones de los derechos humanos en la tradición occidental: a saber, la racionalista y la cristiana; la primera adoptada por la revolución francesa, la última altamente desarrollada en el renacimiento español. Actuales críticas relativistas tratan de negar la universalidad de los derechos humanos alegando que es una ...
openaire   +4 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The future of human rights impact assessments of trade agreements [PDF]

, 2009
The Future of Human Rights Impact Assessments of Trade Agreements develops a methodology for human rights impact assessments of trade agreements and considers whether there is any value in using the methodology on a sustained basis to ensure that the ...
Studie- en Informatiecentrum Mensenrecht, Human Rights in a World of Conflict and Diversity. Conceptualisation and Implementation of Human Rights (t/m 2009), Walker, S.M.   +2 more
core   +1 more source