Results 111 to 120 of about 9,596,602 (303)

Domestic plight : how Jordanian laws, officials, employers, and recruiters fail abused migrant domestic workers / Human Rights Watch

, 2011
"Despite significant legal reforms in recent years, the chances of a migrant domestic worker (MDW) having all her human rights respected and protected in Jordan are slim, if non-existent.
unknown
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The legal architecture of apartheid: Israel’s carceral policies and the erosion of Palestinian rights

Torture
Introduction: This study examines how Israeli domestic legislation, military orders, and judicial practices governing the arrest and detention of Palestinians—intensified after 7 October 2023—operate as a system of discriminatory control across the ...
Layan Kateb, Rania Al-Faqih
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Lawsuit by PMs Letter from Human Rights Watch [PDF]

The Cambodian government - headed bo co-prime ministers at the time - threathened to take legal action against the Phnom Penh Post over an article it said affected "public peace." Human Rights Watch called the government's action an ...
Human Rights Watch
core  

Colonial carcerality and systematic torture: An analysis of Israeli detention practices post-October 7th, 2023

Torture
Introduction: This paper examines Israeli detention practices since 7 October 2023 as a system of colonial carcerality that normalises torture and ill-treatment, benchmarking findings against the Nelson Mandela Rules, the Geneva Conventions, CAT, and ...
jenna abuhasna, Rania Al-Faqih
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

A schematic comparison of regional human rights systems: An update [PDF]

, 2006
There are three regional systems for the protection of human rights, namely: the African, the Inter-American and the European systems. This contribution provides a comparative overview of their salient features and focuses on key procedural and ...
Padilla, D., Studie- en Informatiecentrum Mensenrecht, Heyns, Ch., Human Rights in a World of Conflict and Diversity. Conceptualisation and Implementation of Human Rights (t/m 2009), Zwaak, L.F., Enforcement and supervision of the implementation of Human Rights (t/m 2009)   +5 more
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source