Results 91 to 100 of about 3,808,226 (313)
BMC Pregnancy and Childbirth, 2017 Background Obstetric fistula devastates the lives of women and is found most commonly among the poor in resource-limited settings. Unrepaired third- and fourth-degree perineal lacerations have been shown to be the source of approximately one-third of the
Leeya F. Pinder +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Fact Sheet No.14, Contemporary Forms of Slavery [PDF]
, 1991 Details the variety of human rights violations under the name of slavery and the forms of international cooperation to protect individuals from it, particularly the United Nations role in these ...
Office of the United Nations High Commissioner for Human Rights
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Defensive Enforcement: Human Rights in Indonesia [PDF]
, 2010 The objective of the article is to examine the human rights enforcement in Indonesian legal and political system. This is done by studying the legal basis of human rights, the process of proliferation of human rights discourse, and the actual ...
Hadiprayitno, I.
core +2 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
, 2020 This chapter examines the realisation of human rights education in Norway, as defined by Article 29 (1) b) and d) of the Convention on the Rights of the Child. It examines 1) the legal commitments of Parliament, 2) efforts of the government and 3) data on outcomes concerning attitudes and prejudice against ethnic and religious minorities, children with
openaire +2 more sources
, 2009 The Annual Human Rights Week featuring documentaries, conversations, and guest ...
Boston University Howard Thurman Center for Common Ground
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Support of Epidemiological Well-Being during Regional Event with the International Participation
Эпидемиология и вакцинопрофилактика, 2016 Role of regional cultural mass events as potential threats for epidemics of the dangerous infectious diseases associated with implementation of external and internal epidemiological risks is demonstrated.
A. K. Noskov +6 more
doaj +1 more source