Results 81 to 90 of about 10,020,685 (308)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Human Rights and Fundamental Rights

The growing awareness of the link between the protection and preservation of the environment and the realization of human rights explains why, since the 1970s, we have witnessed a process of greening the traditional list of human and fundamental rights – by fleshing out environmental-related obligations under mainstream human and fundamental rights ...
Rocha, Armando, Oliveira, Heloísa
openaire   +3 more sources

HUMAN RIGHTS AND THE PALESTINIANS

Milletleraras, 1978
Tt is gratifying that concern for human rights is global.There is also a general consensus that respect for human rightsought to be indivisible. The community described as "Palestinian" and that vvhich identifies itself as "Israel" may be betterunderstood and their role in history better evaluated if one assesses the human rights ...
openaire   +3 more sources

A meaningful Human Rights Council in 2030: Catalyse National Rights Protection

, 2016
Rather than celebrating the 10th anniversary of the UN Human Rights Council, we should take a moment to reflect upon what must be improved. This applies not only to States but also to civil society.
Kletzel, Gabriela, Lugon Arantes, Paulo de Tarso, Asano, Camila, Quintanilla, Daniela   +3 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Nurse-midwives’ ability to diagnose acute third- and fourth-degree obstetric lacerations in western Kenya

BMC Pregnancy and Childbirth, 2017
Background Obstetric fistula devastates the lives of women and is found most commonly among the poor in resource-limited settings. Unrepaired third- and fourth-degree perineal lacerations have been shown to be the source of approximately one-third of the
Leeya F. Pinder, Kelsey H. Natsuhara, Thomas F. Burke, Svjetlana Lozo, Monica Oguttu, Leah Miller, Brett D. Nelson, Melody J. Eckardt   +7 more
doaj   +1 more source

Human Rights Groups Condemn KR Attack in Kampot [PDF]

Human Rights groups condemn Khmer Rouge attack in ...
Human Rights Group
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

‘Nowhere and no one is safe’: spatial analysis of damage to critical civilian infrastructure in the Gaza Strip during the first phase of the Israeli military campaign, 7 October to 22 November 2023

Conflict and Health
Background Since the Hamas attacks in Israel on 7 October 2023, the Israeli military has launched an assault in the Gaza Strip, which included over 12,000 targets struck and over 25,000 tons of incendiary munitions used by 2 November 2023. The objectives
Yara Asi, David Mills, P. Gregg Greenough, Dennis Kunichoff, Saira Khan, Jamon Van Den Hoek, Corey Scher, Saleem Halabi, Sawsan Abdulrahim, Nadine Bahour, A. Kayum Ahmed, Bram Wispelwey, Weeam Hammoudeh   +12 more
doaj   +1 more source