Results 101 to 110 of about 10,020,685 (308)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

Irish Human Rights Commission submission to the UN Human Rights Committee on the examination of Ireland's fourth periodic report under the international covenant on civil and political rights

open access: yes, 2004
The Irish Human Rights Commission (IHRC) is Ireland’s National Human Rights Institution (NHRI), set up by the Irish Government under the Human Rights Commission Acts 2000 and 2001.1 The IHRC has a statutory remit under the Human Rights Commission Act ...
Irish Human Rights Commission (IHRC)
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Can human-centred participatory design turn AI into a pertinent tool for human rights research?

open access: yesBig Data & Society
The rapid expansion of artificial intelligence (AI) has triggered significant ethical and human rights concerns. While much of the debate focuses on risks such as discrimination, disinformation and algorithmic bias, much less has been written about AI's ...
Cira Pallí-Asperó   +3 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

SCIENCE IN THE SERVICE OF HUMAN RIGHTS

open access: yes, 2002
Introit -- Pt. I. International standards -- Ch. 1. Links between science and human rights -- Ch. 2. Science in the Universal Declaration of Human Rights -- Ch. 3.
Claude, Richard Pierre
core  

Pathways to protection: a human rights-based response to the flight of asylum seekers by sea [PDF]

open access: yes, 2016
The Commission has endeavoured to identify options for responding to flight by sea which are consistent with Australia’s international human rights obligations.
Australian Human Rights Commission
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

“Gay Rights are Human Rights”: the Framing of New Interpretations of International Human Rights Norms [PDF]

open access: yes, 2014
The purpose of this chapter is to explore the development of the framing of the rights of lesbian, gay, bisexual, and transgender (LGBT) persons and sexual orientation and gender identity in terms of a human rights paradigm. This decades-long process involved many actors, from within academia, gay and lesbian nongovernmental organizations (NGOs), such ...
openaire   +3 more sources

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