Results 101 to 110 of about 3,808,226 (313)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Public Health Reviews, 2017 The Human Rights in Patient Care framework embraces general human rights principles applicable to both patients and health care providers in the delivery of health care.
Ximena Andión Ibañez +1 more
doaj +1 more source
Legal pluralism as a human right and/or as a human rights violation [PDF]
, 2017 INTERNATIONAL HUMAN RIGHTS law can be analysed in terms of legal pluralism. In public opinion, ‘ human rights ’ are often portrayed as a clear and homogenous concept. Yet those who work in the field of human rights know that the reality is very different.
Brems, Eva
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Child Labor and Environmental Health: Government Obligations and Human Rights
International Journal of Pediatrics, 2012 The Convention concerning the Prohibition and Immediate Action for the Elimination of the Worst Forms of Child Labour was adopted by the International Labour Organization in 1999.
Joseph J. Amon +3 more
doaj +1 more source
Evolutionary Anthropology: Issues, News, and Reviews, 2017 AbstractFossil hominids often processed material held between their upper and lower teeth. Pulling with one hand and cutting with the other, they occasionally left impact cut marks on the lip (labial) surface of their incisors and canines. From these actions, it possible to determine the dominant hand used.
Lozano, María +8 more
openaire +3 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
The Role of Parents in Addressing the Discipline Problems of Children at School
Profesi Pendidikan DasarThe study presented in this article explores a previously under-researched area: the role of parents in managing their children’s discipline problems in South African schools.
Nicholus Tumelo Mollo +4 more
doaj +1 more source
The role of UN agencies and programmes in activating human security [PDF]
الرافدین للحقوقThe concept of human security is a modern concept in international studies, as the conditions following the end of the cold war that the traditional concept of security based on State security was incapable to face the new challenges .
Shahad Al-Mulki, Ayad Al-Saqalli
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source