Results 61 to 70 of about 3,808,226 (313)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
“What is there left after losing oneself?”: 100 testimonies of genocidal torture from Gaza
TortureIntroduction: Since 7 October 2023, the number of Palestinians detained by Israeli authorities has increased dramatically. Methods: Semi-structured in-depth interviews were conducted between December 2023 and November 2024 with 100 Palestinians who ...
Maha Aon +7 more
doaj +1 more source
Migrant Rights are Human Rights [PDF]
, 2009 Although it is the case that a rights discourse has become part of everyday language, the discourse remains relatively weak when it comes to migrant workers in Canada and around the world. Most certainly, the rights discourse has not been translated into
Hennebry, Jenna
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Frontiers in AgingBackgroundUnwanted loneliness among older adults has become a growing public health concern, particularly in rural contexts characterized by population aging, depopulation, and limited access to services.
A. Yurrebaso +3 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Are New Technologies an Aid to Reputation as a Disciplinarian?
AJIL Unbound, 2019 Kristina Daugirdas offers a different vantage point from most scholarship on the accountability of international organizations (IOs) by examining whether a focus on reputation can address accountability deficits.
Lorna McGregor
doaj +1 more source
Sub-regional Meeting on Disability Legislation: Decent Work for Persons with Disabilities in Asia, UN Conference Centre, Bangkok, Thailand, 23-24 June 2008 [PDF]
, 2008 The Sub-regional Meeting on Disability Legislation, jointly organized by the ILO and the Office of the High Commissioner for Human Rights (OHCHR), took place in the framework of a technical cooperation project, “Promoting the Employability and Employment
ILO, Office of the High Commissioner for Human Rights (OHCHR) and Irish Aid
core +1 more source