Results 51 to 60 of about 587,142 (266)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Health Is a Human Right, Right?

American Journal of Public Health, 2008
The constitution of the World Health Organization states that “The enjoyment of the highest attainable standard of health is one of the fundamental rights of every human being.”1(p1) Although this perspective is notable and has proven to be significant in promoting the quality of life among individuals worldwide, it is unfortunate that this resounding ...
openaire   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Povrede prava zajamčenih Europskom konvencijom za zaštitu ljudskih prava i temeljnih sloboda utvrđene u području upravnog prava u Republici Hrvatskoj – izabrane presude Europskog suda za ljudska prava

Zbornik Pravnog Fakulteta Sveučilišta u Rijeci
Sustav zaštite ljudskih prava uspostavljen Europskom konvencijom za zaštitu ljudskih prava i temeljnih sloboda ostvaruje se kroz nadležnost Europskog suda za ljudska prava da ispituje pojedinačne zahtjeve u kojima se podnositelji žale na povrede ...
Zvonimir Mataga, Franka Viljac Herceg
doaj   +1 more source

Depression and Anxiety among Iraqi Women: A Systematic Review

Erbil Journal of Nursing and Midwifery, 2018
Background and objective: Maternal mental health is considered an important subject among leading public health experts. Women are two to three times more likely to be diagnosed with mental illness compared to men.
Kathryn Mishkin, Bibi Chaterpateah, Valerie Bresier, Jaleen Fraser   +3 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Islandness in human rights, human rights in islandness: Missing voices

Island Studies Journal, 2023
Island Studies literature has rarely engaged with human rights law to scrutinise how the development of human rights standards and/or their (in)efficient implementation on islands contour the lives of islanders and islandness itself. Along similar lines, human rights research and practice do not systematically take into account islandness and Island ...
openaire   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Private Governance of Freedom of Expression on Social Media Platforms: EU content regulation through the lens of human rights standards

Nordicom Review, 2020
For years, social media platforms have been perceived as a democratic gain, facilitating freedom of expression, easy access to a variety of information, and new means of public participation.
Jørgensen Rikke Frank, Zuleta Lumi
doaj   +1 more source