Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Introduction: SDG 16, Higher Education, and the Benefits of New Approaches to Teaching and Researching Human Rights [PDF]
Sarah E. Mendelson
openalex +1 more source
On Becoming Human and Being Humane: Human Rights, Women’s Rights, Species Rights
ReligionsThis essay focuses on the nexus of vulnerability and rights. It argues that in transforming vulnerability from a stigma that alienated women from their humanity to the signature of human dignity, women bridged the gap between the liberatory promise of human rights and its exploitative patriarchal politics. It finds that the ideas of Mary Wollstonecraft,
openaire +2 more sources
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Responsibility to Respect: Why the Core Company Should Act When Affiliates Infringe Human Rights
, 2012 Radu Mares
openalex +1 more source
Prescription for Failure: Health & Intellectual Property in the Dominican Republic [PDF]
, 2010 Georgetown University Law Center, Human Rights Institute
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Addressing genetic discrimination and its stigmatizing effects through human rights. [PDF]
J Community GenetRud A, Porter E, Joly Y, Uberoi D.
europepmc +1 more source
Human Rights Treaty Bodies, Proceduralization and the Development of Human Rights Jus Commune
, 2015 Kasey McCall-Smith
openalex +1 more source
Refugee Crisis in America: Iraqis and Their Resettlement Experience [PDF]
, 2009 Georgetown University Law Center, Human Rights Institute
core +1 more source