Results 111 to 120 of about 10,145,519 (298)

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

A meaningful Human Rights Council in 2030: Catalyse National Rights Protection

, 2016
Rather than celebrating the 10th anniversary of the UN Human Rights Council, we should take a moment to reflect upon what must be improved. This applies not only to States but also to civil society.
Kletzel, Gabriela, Lugon Arantes, Paulo de Tarso, Asano, Camila, Quintanilla, Daniela   +3 more
core  

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

FEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court, Nigel Francis, Andrew Shore, Stephen Rutherford   +3 more
wiley   +1 more source

Secure Childcare and the Convention on the Rights of Persons with Disabilities: Illuminating the Applicable Rights Framework

Social Sciences
Case law illustrates both the complexity of the regimes in England and Wales whereby children may be deprived of their liberty for welfare reasons and the inadequacy of provision to meet complex needs, which has led to a significant use of the power of ...
Kris Gledhill
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Human Rights Groups Condemn KR Attack in Kampot [PDF]

Human Rights groups condemn Khmer Rouge attack in ...
Human Rights Group
core  

Ethics Committees and Human Rights

Medicina e Morale
Not available.
openaire   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Panel debate on ensuring human rights in the global economy : the role of the WTO

, 1999
Panel debate co-organized by International NGO Committee on Human Rights in Trade and Investment (INCHRITI). Panelists include: Sakiko Fukada-Parr (Human Development Report Office, UNDP), Alec Irwin (Minister of Trade and Industry, South Africa), Peter ...
People's Decade for Human Rights Education (PDHRE)
core  

Internal fight : Palestinian abuses in Gaza and the West Bank / Human Rights Watch

, 2008
"This report documents serious human rights abuses over the past year by the competing Palestinian authorities in Gaza and the West Bank, run by Hamas and Fatah, respectively.
unknown
core   +1 more source