Results 91 to 100 of about 1,602,123 (303)
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
The Local is Global: Broker for Human Rights “Florence Kitchelt, Connecticut Peace Activist and Feminist,” 1920-1961 [PDF]
, 2009 In this paper, I will explore the role of local peace activist and feminist, Florence Ledyard Kitchelt (1874-1961) in supporting social justice, equality, and world peace.
Moon, Danelle L
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
International legal means of protecting human rights and freedoms
Теорія і практика правознавства, 2019 The article deals with the application of international legal means of protection of human rights and freedoms in Ukraine. The content of the main acts of international law, which guarantee the ability to protect their rights and freedoms from illegal ...
Олександр Миколайович Похил
doaj +1 more source
The right to education in human rights governance and politics: reporting and monitoring intercultural education [PDF]
, 2011 The right to education, as outlined in the Convention on the Rights of the Child (CRC) 1989, recognises the increasing multiculturalism of nation states and obligates governments to reform national curricula to reflect these changes, and to report on ...
Gamarnikow, Eva
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Discourse in Development: Viewing the United Nations Committee on Economic, Social and Cultural Rights through the Post-Colonial Lens [PDF]
This article uses post-colonial theory to examine the cluster of international human rights known as economic, social and cultural rights. The article surveys the jurisprudence of the UN Committee on Economic, Social and Cultural Rights, making it ...
Beth Lyon
core +1 more source
The Dynamic Impact of Periodic Review on Women’s Rights [PDF]
, 2018 Human rights treaty bodies have been frequently criticized as useless and the regime’s self-reporting procedure widely viewed as a whitewash. Yet very little research explores what, if any, influence this periodic review process has on governments ...
Creamer, Cosette D., Simmons, Beth A.
core +2 more sources
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source