Results 131 to 140 of about 8,954,431 (357)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Teaching and Learning Science as a Tool for Human Sustenance: The Non-Science Community’s Expectations for School Science

Education Sciences
The world, through the UN and its agencies, is looking for ways to sustain the environment that we live in via the SDGs. The importance of school science in achieving the SDGs cannot be overstressed.
Kenneth Adu-Gyamfi, Isaiah Atewini Asaki, Abigail Fiona Dzidzinyo, Charles Deodat Otami   +3 more
doaj   +1 more source

The (human) science of medical virtual learning environments. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2011
Stone RJ.
europepmc   +1 more source

Intrapartum electronic fetal monitoring: imperfect technologies and clinical uncertainties—what can a human factors and social science approach add? [PDF]

Jane Sandall
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Impacts of road development in sub-Saharan Africa: A call for holistic perspectives in research and policy

iScience
Summary: This perspective explores the multifaceted development challenges related to road network expansion in sub-Saharan Africa, where recent infrastructure investments reflect transformative ambitions but also imply socio-ecological tradeoffs.
Lisa Biber-Freudenberger, Christina Bogner, Georg Bareth, Michael Bollig, Peter Dannenberg, Javier Revilla Diez, Clemens Greiner, Philipo Jacob Mtweve, Britta Klagge, Tanja Kramm, Detlef Müller-Mahn, Vincent Moseti, Nicodemus Nyamari, Dennis Otieno Ochuodho, Elias Kuntashula, Theobald Theodory, Jessica Paula Rose Thorn, Jan Börner   +17 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The Impact Of Selective Human Resources Management Practices On The Employee’s Competences At Jordanian Private Universities:, Case Study On Applied Science, Philadelphia, And Al-Zaytoneh Universities

, 2019
Abdallah Shibli Alshibli
openalex   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source