Results 131 to 140 of about 2,753,266 (267)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Full Issue, Volume 5, Number 2

open access: yesJournal of Human Sciences and Extension, 2017
Journal of Human Sciences and Extension
doaj  

Optimal control of Typhoid fever transmission under environmental and public health interventions. [PDF]

open access: yesPLoS One
Amoah-Mensah J   +4 more
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

open access: yesFEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Full Issue, Volume 2, Number 2

open access: yesJournal of Human Sciences and Extension, 2014
Journal of Human Sciences and Extension
doaj  

The emerging role of the meningeal lymphatic and glymphatic systems in migraine pathophysiology: a systematic review. [PDF]

open access: yesJ Headache Pain
Bagheri K   +7 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Full Issue, Volume 4, Number 1

open access: yesJournal of Human Sciences and Extension, 2016
Journal of Human Sciences and Extension
doaj  

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