Results 91 to 100 of about 426,418 (303)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Performance Prediction and Analysis of Solar-Assisted Ground-Source Heat Pump Systems in Typical Rural Areas, China

Energies
The increasingly severe energy crisis and associated environmental issues pose new challenges for the efficient and rational utilization of renewable energy.
Ying Cao, Zhibin Zhang, Guosheng Jia, Jianyu Zhai, Jianke Hao, Meng Zhang, Liwen Jin   +6 more
doaj   +1 more source

What Are the Factors Behind Pay Settlements? Evidence from Spanish and British Data [PDF]

This article presents a study of the determinants of pay settlements in a sample of Spanish and British establishments. We find that variables such as establishment size and age, foreign ownership, labour costs, the existence of internal labour markets ...
Bayo-Moriones, Alberto, Galdón-Sánchez, José Enrique, Martinez-de Moretin, Sara   +2 more
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Study on GIS Visualization in Evaluation of the Human Living Environment in Shenyang-Dalian Urban Agglomeration

Scientifica, 2016
Analysis of human living environmental quality of Shenyang-Dalian urban agglomerations has important theoretical and practical significance in rapid development region.
Kang Hou, Jieting Zhou, Xuxiang Li, Shengbin Ge   +3 more
doaj   +1 more source

Comprehensive Evaluation and Analysis of Human Settlements' Suitability in the Yangtze River Delta Based on Multi-Source Data. [PDF]

Int J Environ Res Public Health, 2023
Liu H, Li X, Guan Y, Li S, Sun H.
europepmc   +1 more source

A sacred landscape: an enquiry of the “Cubas” from the South of Portugal [PDF]

, 2014
Ponencia presentada a Session 9: Forma urbana y relaciones entre historia y proyecto: el medio ambiente como patrimonio / Urban form and relationships between design and history: environmental heritage, arquitecture and planningThe purpose of this paper ...
Ferro, Luís
core  

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Distance from human settlements favors wild-type appearance of feral cats (Felis catus) in Mediterranean woodland. [PDF]

Ecol Evol, 2023
Dubiner S, Namir I, Chen R, Levin E.
europepmc   +1 more source

Shelter Development Through Cooperatives: A Strategy for Poverty Alleviation and Slum Improvement for Asia and the Pacific Region [PDF]

, 2002
The research traces the flow of humanity from the urban areas to the cities thus creating severe economic and social problems in the cities thus leading to homelessness; lack of sanitation; health hazards; crimes; vandalism; drugs; children wandering ...
M. L. Khurana
core