Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The Impact of System Softness on Haines Jumps and Drainage in Porous Media
Water Resources ResearchHaines jumps are abrupt movements of fluid interfaces accompanied by sudden changes in capillary pressure during multiphase flow in porous media. They are a fundamental pore‐scale mechanism influencing displacement patterns and efficiency.
Bowen Zhang +3 more
doaj +1 more source
High-Rise Residential District Morphology Optimization for Enhancing the Green Space Cooling Effect
BuildingsLarge-scale urban green spaces exert a cooling effect in cities and have great potential for optimizing the urban climate. In this study, taking the typical green space Xingfulindai in Xi’an as an example, we carried out field measurements and ENVI-met ...
Feng Shi +3 more
doaj +1 more source
The agglomeration and dispersion dichotomy of human settlements on Earth. [PDF]
Sci Rep, 2021 Strano E +4 more
europepmc +1 more source
Building Towards a Future in Which Urban Sanitation Leaves No One Behind [PDF]
, 2015 Plans to improve access to sanitation in towns and cities of the global South are hampered by multiple challenges. One is a lack of reliable information.
Diana Mitlin
core
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
The Face of Urban Poverty Explaining the Prevalence of Slums in Developing Countries [PDF]
One of the most visible and enduring manifestations of urban poverty in developing countries is the formation and proliferation of slums. While attention has focused on the rapid pace of urbanization as the sole or major factor explaining the ...
Arimah, C. Ben
core
Access to Water in the Slums of the Developing World [PDF]
, 2009 The text and data in this publication may be reproduced as long as the source is cited. Reproductions for commercial purposes are forbiddenThe discussion reveals the failure of public policies as well as markets to provide satisfactory solutions to the ...
Dagdeviren, Hulya, Robertson, Simon A.
core
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
Optimisation of Garbage Bin Layout in Rural Infrastructure for Promoting the Renovation of Rural Human Settlements: Case Study of Yuding Village in China. [PDF]
Int J Environ Res Public Health, 2021 Shen Y, Wang C.
europepmc +1 more source