Results 21 to 30 of about 427,819 (300)
Buildings, 2022 To optimize the seismic performance of a new type of steel-concrete tower, a 120 m steel-concrete composite tower model with a tuned mass damper (TMD) was constructed in ABAQUS for simulation analysis.
Yanchao Yue +4 more
doaj +1 more source
Punishing Pharmaceutical Companies for Unlawful Promotion of Approved Drugs: Why the False Claims Act is the Wrong Rx [PDF]
, 2008 This article criticizes the shift in focus from correction and compliance to punishment of pharmaceutical companies allegedly violating the Food, Drug, & Cosmetic Act (FD&C Act) prohibitions on unlawful drug promotion.
Girard, Vicki W.
core +2 more sources
Mapping Human Settlements from Space [PDF]
, 2015 This booklet describes the Global Human Settlement Layer for mapping human presence using satellite imagesJRC.A.6 ...
core +1 more source
Atmosphere, 2022 Rapid urban expansion leads to the continuous deterioration of the urban thermal environment, which endangers the sustainable development of the city; meanwhile, countries all over the world are becoming increasingly interested in the mitigating effects ...
Jiajie Hou +3 more
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Systems approaches to human settlements [PDF]
Papers of the Regional Science Association, 1977 Regional and urban policies always have consequences for the whole of the national territory, whether or not they were intended to do so. Thus policy makers should have a reasonably good grasp of the structure of human settlement systems and of the nature of the processes that underlie evolving settlement patterns.
openaire +2 more sources
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Scientific ReportsUniversity open spaces are predominantly utilized by students, with outdoor thermal comfort on campus significantly enhancing their physical and mental well-being. This study investigates the thermal perceptions (sensation, comfort, and acceptability) of
Wenqiang Jing +6 more
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source