Results 101 to 110 of about 976,647 (347)

G-CSF does not influence C2C12 myogenesis despite receptor expression in healthy and dystrophic skeletal muscle [PDF]

, 2014
Granulocyte-colony stimulating factor (G-CSF) increases recovery of rodent skeletal muscles after injury, and increases muscle function in rodent models of neuromuscular disease.
Brown, Erin L., Della-Gatta, Paul A., Lynch, Gordon S., Russell, Aaron P., Ward, Alister C., Wright, Craig R.   +5 more
core   +2 more sources

Reduced Muscular Carnosine in Proximal Myotonic Myopathy—A Pilot 1H‐MRS Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Myotonic dystrophy type 2 (proximal myotonic myopathy, PROMM) is a progressive multisystem disorder with muscular symptoms (proximal weakness, pain, myotonia) and systemic manifestations such as diabetes mellitus, cataracts, and cardiac arrhythmias.
Alexander Gussew, Maryam Kargaran, Maik Rothe, Andreas Deistung, Dietrich Stoevesandt, Walter A. Wohlgemuth, David Strube, Thomas Kendzierski, Anna Katharina Kölsch, Maurits Gerhard Abraham Heuschen, Markus Otto, Alexander Mensch   +11 more
wiley   +1 more source

Engineering a 3D in vitro model of human skeletal muscle at the single fiber scale.

PLoS ONE, 2020
The reproduction of reliable in vitro models of human skeletal muscle is made harder by the intrinsic 3D structural complexity of this tissue. Here we coupled engineered hydrogel with 3D structural cues and specific mechanical properties to derive human ...
Anna Urciuolo, Elena Serena, Rusha Ghua, Susi Zatti, Monica Giomo, Nicolò Mattei, Massimo Vetralla, Giulia Selmin, Camilla Luni, Nicola Vitulo, Giorgio Valle, Libero Vitiello, Nicola Elvassore   +12 more
doaj   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

The human skeletal muscle in vivo : The use of microdialysis to study glucose metabolism and insulin resistance [PDF]

, 2004
The aim of this thesis was to further develop the microdialysis technique for studies of glucose metabolism and insulin resistance in human skeletal muscle in vivo and to use this technique to explore the effect of exercise on muscle glucose metabolism ...
Hamrin, Kerstin
core  

Muscle carnosine metabolism and β-alanine supplementation in relation to exercise and training [PDF]

, 2010
Carnosine is a dipeptide with a high concentration in mammalian skeletal muscle. It is synthesized by carnosine synthase from the amino acids L-histidine and beta-alanine, of which the latter is the rate-limiting precursor, and degraded by carnosinase ...
Baguet, Audrey, Beeckman, Sam, Derave, Wim, Everaert, Inge   +3 more
core   +2 more sources

Aging of human skeletal muscles.

Collegium antropologicum, 2005
Normal aging in humans is associated with progressive decrease in skeletal muscle mass and strength (sarcopenia) which contributes to frailty and falls. The age associated changes in body composition result from lower levels of anabolic hormones, oxidative damage, neuromuscular alterations and a general decrease in muscle protein turnover.
Nikolić, Marina, Bajek, Snježana, Bobinac, Dragica, Šoić Vranić, Tamara, Jerković, Romana   +4 more
openaire   +4 more sources

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

Metabolic and molecular regulation in skeletal muscle dysfunction and regeneration

Frontiers in Cell and Developmental Biology
Skeletal muscle is an important organ in the human body for maintaining overall strength and mobility. Skeletal muscle has the capability of self-regeneration, which can be achieved by utilizing specific energy pathways.
Jong Beom Jin, Angelique Robinson, Tori Soukup, Ember Black, André Abit, André Abit, Shane M. Hammer, Anna Han, Anna Han, Edralin Lucas, Yoo Kim, Jiyoung Bae   +11 more
doaj   +1 more source

The genetic regulatory signature of type 2 diabetes in human skeletal muscle

Nature Communications, 2016
Type 2 diabetes (T2D) results from the combined effects of genetic and environmental factors on multiple tissues over time. Of the >100 variants associated with T2D and related traits in genome-wide association studies (GWAS), >90% occur in non-coding ...
L. Scott, M. Erdos, J. Huyghe, R. Welch, Andrew Beck, B. Wolford, P. Chines, John P. Didion, Narisu Narisu, H. Stringham, D. L. Taylor, A. Jackson, Swarooparani Vadlamudi, L. Bonnycastle, L. Kinnunen, J. Saramies, J. Sundvall, Ricardo D’Oliveira Albanus, A. Kiseleva, John Hensley, G. Crawford, Hui Jiang, Xiaoquan Wen, R. Watanabe, T. Lakka, K. Mohlke, M. Laakso, J. Tuomilehto, H. Koistinen, M. Boehnke, F. Collins, Stephen C. J. Parker   +31 more
semanticscholar   +1 more source