Results 141 to 150 of about 976,647 (347)

Co-expression of SERCA isoforms, phospholamban and sarcolipin in human skeletal muscle fibers.

PLoS ONE, 2013
Sarcolipin (SLN) and phospholamban (PLN) inhibit the activity of sarco(endo)plasmic reticulum Ca(2+)-ATPases (SERCAs) by reducing their apparent affinity for Ca(2+).
Val A Fajardo, Eric Bombardier, Chris Vigna, Tahira Devji, Darin Bloemberg, Daniel Gamu, Anthony O Gramolini, Joe Quadrilatero, A Russell Tupling   +8 more
doaj   +1 more source

Biofilm‐Antagonist Ginger‐Based 3D‐Printable Photoresins for Complex Implant Designs Exhibiting Advanced Multifunctional Biomedical Applications

Advanced Materials, EarlyView.
This work offers unique Ginger‐based 3D‐printable resins that can print customizable high‐resolution complex designs. The customizable printing backbone of Zingerol prints also mimics various human bones' strength. Acquisition of in‐vivo biocompatibility in rat model with no severe inflammatory response, along with in‐vitro antioxidant and ex‐vivo anti‐
Simran Jindal, Majd Bisharat, Bassma Khamaisi, Krishanu Ghosal, Eid Nassar‐Marjiya, Qi Wu, Shadi Daoud, Idan Redenski, Samer Srouji, Shady Farah   +9 more
wiley   +1 more source

Muscling in on the third dimension

eLife, 2015
The development of a functional three-dimensional model of human skeletal muscle tissue could accelerate progress towards new and personalized treatments for skeletal muscle disorders.
Mohsen Afshar Bakooshli, Penney M Gilbert   +1 more
doaj   +1 more source

Mimicking exercise in three-dimensional bioengineered skeletal muscle to investigate cellular and molecular mechanisms of physiological adaptation [PDF]

Bioengineering of skeletal muscle in vitro in order to produce highly aligned myofibres in relevant three dimensional (3D) matrices have allowed scientists to model the in vivo skeletal muscle niche.
Kasper, AM, Martin, NRW, Sharples, AP, Turner, DC   +3 more
core   +1 more source

Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs

eLife, 2015
Existing in vitro models of human skeletal muscle cannot recapitulate the organization and function of native muscle, limiting their use in physiological and pharmacological studies.
Lauran R. Madden, Mark Juhas, W. Kraus, G. Truskey, N. Bursac   +4 more
semanticscholar   +1 more source

Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application

Advanced Materials, EarlyView.
This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong, You Zhou, Qingxiu Li, Wenyu Zhao, Sunyingyue Geng, Hangfei Li, Yan‐Bing Leng, Shirui Zhu, Guanglong Ding, Yongbiao Zhai, Ziyu Lv, Ye Zhou, Su‐Ting Han   +12 more
wiley   +1 more source

Skeletal Muscle-Specific Methyltransferase METTL21C Trimethylates p97 and Regulates Autophagy-Associated Protein Breakdown

Cell Reports, 2018
Summary: Protein aggregates and cytoplasmic vacuolization are major hallmarks of multisystem proteinopathies (MSPs) that lead to muscle weakness. Here, we identify METTL21C as a skeletal muscle-specific lysine methyltransferase.
Janica Lea Wiederstein, Hendrik Nolte, Stefan Günther, Tanja Piller, Martina Baraldo, Sawa Kostin, Wilhelm Bloch, Natalie Schindler, Marco Sandri, Bert Blaauw, Thomas Braun, Soraya Hölper, Marcus Krüger   +12 more
doaj   +1 more source

Anomalous Kv 7 channel activity in human malignant hyperthermia syndrome unmasks a key role for H2 S and persulfidation in skeletal muscle. [PDF]

BACKGROUND AND PURPOSE: Human malignant hyperthermia (MH) syndrome is induced by volatile anaesthetics and involves increased levels of cystathionine β-synthase (CBS)-derived H2 S within skeletal muscle.
Basso Elisabetta, Maria, Bibli Iris, Sophia, Bucci, Mariarosaria, Calderone, Vincenzo, Cirino, Giuseppe., Citi, Valentina, Cozzolino, Catia, de Dominicis, Gianfranco, Fleming, Ingrid, Mancini, Antonio, Manzo, ONORINA LAURA, Mariniello, Martina, Martelli, Alma, Panza, Elisabetta, Vallifuoco, Marianna, Vellecco, Valentina   +15 more
core   +1 more source

Ultrasound in Women's Health: Mechanisms, Applications, and Emerging Opportunities

Advanced Materials, EarlyView.
As healthcare moves toward decentralization, ultrasound technologies are evolving from strictly imaging tools in clinical settings into versatile diagnostic and therapeutic platforms, with growing roles addressing women's health needs. This review highlights how ultrasound's underlying physical mechanisms can be harnessed to reduce disparities in women'
Sarah B. Ornellas, Bilal Kizilaslan, Aastha Shah, Jason F. Hou, Yoonsoo Shin, Alejandra Hernandez Moyers, Claudia Lozano, Canan Dagdeviren   +7 more
wiley   +1 more source

MicroRNAs promote skeletal muscle differentiation of mesodermal iPSC-derived progenitors

Nature Communications, 2017
Mesodermal iPSC-derived progenitors (MiPs) can regenerate both skeletal and cardiac muscle. Here, the authors show that a microRNA cocktail stimulates skeletal muscle differentiation and that human MiPs can engraft into striated muscle in mice.
Giorgia Giacomazzi, Bryan Holvoet, Sander Trenson, Ellen Caluwé, Bojana Kravic, Hanne Grosemans, Álvaro Cortés-Calabuig, Christophe M. Deroose, Danny Huylebroeck, Said Hashemolhosseini, Stefan Janssens, Elizabeth McNally, Mattia Quattrocelli, Maurilio Sampaolesi   +13 more
doaj   +1 more source