Results 71 to 80 of about 976,647 (347)

An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondrial metabolism

Molecular Metabolism, 2017
Objective: Strategies improving skeletal muscle mitochondrial capacity are commonly paralleled by improvements in (metabolic) health. We and others previously identified microRNAs regulating mitochondrial oxidative capacity, but data in skeletal muscle ...
Dennis Dahlmans, Alexandre Houzelle, Pénélope Andreux, Johanna A. Jörgensen, Xu Wang, Leon J. de Windt, Patrick Schrauwen, Johan Auwerx, Joris Hoeks   +8 more
doaj   +1 more source

Aging affects the transcriptional regulation of human skeletal muscle disuse atrophy. [PDF]

PLoS ONE, 2012
Important insights concerning the molecular basis of skeletal muscle disuse-atrophy and aging related muscle loss have been obtained in cell culture and animal models, but these regulatory signaling pathways have not previously been studied in aging ...
Charlotte Suetta, Ulrik Frandsen, Line Jensen, Mette Munk Jensen, Jakob G Jespersen, Lars G Hvid, Monika Bayer, Stine J Petersson, Henrik D Schrøder, Jesper L Andersen, Katja M Heinemeier, Per Aagaard, Peter Schjerling, Michael Kjaer   +13 more
doaj   +1 more source

Accumulation of muscle ankyrin repeat protein transcript reveals local activation of primary myotube endcompartments during muscle morphogenesis [PDF]

, 1997
The characteristic shapes and positions of each individual body muscle are established during the process of muscle morphogenesis in response to patterning information from the surrounding mesenchyme. Throughout muscle morphogenesis, primary myotubes are
Adams, Aigner, Arber, Arber, Arber, Ashby, Blank, Buckingham, Chevallier, Chien, Chiquet, Chu, Condon, Connor, deLapeyriére, Duxson, Fontaine, Gatchalian, Grayson, Hauschka, Hilfer, Imaizumi-Scherrer, Jellies, Lance-Jones, Lanser, McMahon, Olson, Ontell, Rechsteiner, Ross, Schaeren-Wiemers, Schroeter, Schroeter, Shaw, Sweeney, Tucker, Witzemann, Zou   +37 more
core   +3 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

The role of adipokines in skeletal muscle inflammation and insulin sensitivity

Journal of Inflammation, 2018
Background There is currently an unmet clinical need to develop better pharmacological treatments to improve glucose handling in Type II Diabetes patients with obesity.
Thomas Nicholson, Chris Church, David J. Baker, Simon W. Jones   +3 more
doaj   +1 more source

Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle [PDF]

, 2016
The development of skeletal muscle insulin resistance is an early physiological defect, yet the intracellular mechanisms accounting for this metabolic defect remained unresolved. Here, we have examined the role of glucose-6-phosphate dehydrogenase (G6PDH)
Bruce, CR, Colgan, TD, Drummond, GR, Febbraio, MA, Greenfield, JR, Gregorevic, P, Henstridge, DC, Hoffman, NJ, Hong, YH, Iliades, P, Kingwell, BA, Kraakman, MJ, Lee-Young, RS, Lynch, GS, McConell, Glenn, Murphy, KT, Samocha-Bonet, D, Siebel, AL, Zivanovic, B   +18 more
core   +4 more sources

Repeated exposure to heat stress induces mitochondrial adaptation in human skeletal muscle.

Journal of applied physiology, 2018
The heat stress response is associated with several beneficial adaptations that promote cell health and survival. Specifically, in vitro and animal investigations suggest that repeated exposures to a mild heat stress (~40°C) elicit positive mitochondrial
Paul S. Hafen, Coray N. Preece, Jacob R. Sorensen, C. Hancock, Robert D Hyldahl   +4 more
semanticscholar   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Sphingosine-1-Phosphate Signaling Regulates Myogenic Responsiveness in Human Resistance Arteries. [PDF]

PLoS ONE, 2015
We recently identified sphingosine-1-phosphate (S1P) signaling and the cystic fibrosis transmembrane conductance regulator (CFTR) as prominent regulators of myogenic responsiveness in rodent resistance arteries.
Sonya Hui, Andrew S Levy, Daniel L Slack, Marcus J Burnstein, Lee Errett, Daniel Bonneau, David Latter, Ori D Rotstein, Steffen-Sebastian Bolz, Darcy Lidington, Julia Voigtlaender-Bolz   +10 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source