Results 111 to 120 of about 9,653,551 (300)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

A single-cell multi-omics atlas of human eyelid skin

Frontiers in Genetics
The skin acts as the first barrier protecting the human body against the external environment. Transcriptional heterogeneity in human skin is widely confirmed, but the regulatory mechanisms remain largely unexplored.
Weiguang Ma, Weiguang Ma, Weiguang Ma, Weiguang Ma, Yanwen Xu, Junjie Chen, Junjie Chen, Junjie Chen, Yue Yuan, Yue Yuan, Yue Yuan, Xiaoyu Wei, Xiaoyu Wei, Xiaoyu Wei, Qiuting Deng, Qiuting Deng, Qiuting Deng, Qiuting Deng, Ruikang Li, Ruikang Li, Ruikang Li, Jiaxin Du, Jiaxin Du, Jiaxin Du, Zhongjin Zhang, Zhongjin Zhang, Zhongjin Zhang, Zhentao Zhou, Quhuan Li, Haiyan Shen, Jufang Zhang, Jufang Wang, Pengfei Cai, Pengfei Cai, Pengfei Cai, Pengcheng Guo, Pengcheng Guo, Pengcheng Guo   +37 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Quality-by-Design Development of a Clofazimine–Pyrazinamide Dermal Emulsion and Its Diffusion Behavior in Strat-M^® and Human Skin

Pharmaceuticals
Background/Objectives: Topical treatment of cutaneous tuberculosis (CTB) requires reliable models to evaluate dermal drug release and diffusion, particularly for fixed-dose combinations (FDCs) with contrasting physicochemical properties.
Francelle Bouwer, Marius Brits, Daniélle van Staden, Joe M. Viljoen   +3 more
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Human epidermal resident memory T cells: beyond the dermal perspective

Frontiers in Immunology
The concept of tissue-resident memory T (TRM) cells has fundamentally transformed our understanding of peripheral immune surveillance. Although skin TRM biology has been extensively studied, most investigations have focused on the dermis, whereas the ...
Youichi Ogawa, Takuya Sato, Lisa Minai, Manao Kinoshita, Shinji Shimada, Tatsuyoshi Kawamura   +5 more
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Alpha-1 adrenoceptor stimulation triggers axon-reflex vasodilatation in human skin [PDF]

, 2009
The aim of this study was to determine whether pre-treatment of human skin with the α1-adrenoceptor antagonist terazosin would block vasoconstrictor responses and axon-reflex vasodilatation to the α1-adrenoceptor agonist methoxamine.
Drummond, P.D.
core  

Variation of skin properties within human forearms demonstrated by non-invasive detection and multi-way analysis

, 2002
Background: It is known that the properties of human skin vary locally. The purpose of this study was to investigate the properties of human volar forearms even further using advanced non-invasive techniques and numerical methods.
Geladi, P., Ollmar, Stig, Aberg, P., Åberg, Peter, Nicander, I, ., Geladi, Paul,, Nicander, Ingrid   +6 more
core   +1 more source