Results 91 to 100 of about 141,242 (314)

Stem Cell Differentiation Disperses Transcriptional Clusters via a Conserved Surface‐Condensate Trajectory

Advanced Science, EarlyView.
Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg, Irina Wachter, Agnieszka Pancholi, Matthias Akyel, Yomna Gohar, Priya Kumar, Ana Miguel Fernandes, Yuzhi Bao, Alica Schmidt‐Heydt, Marcel Piepers, Alicia Günthel, Marcel Sobucki, Elisa Kämmer, Süheyla Eroğlu‐Kayıkçı, Stephan Allgeier, Sylvia Erhardt, Vasily Zaburdaev, Carmelo Ferrai, Lennart Hilbert   +18 more
wiley   +1 more source

Trends in male semen parameters (2011–2018): a large-scale retrospective analysis of 5,886 cases based on the fifth edition WHO manual

Frontiers in Public Health
ImportanceGlobal reports suggest declining sperm quality, but data from Asian populations under standardized conditions are limited. Investigating trends in China is critical for understanding modifiable factors affecting male fertility.ObjectiveTo ...
Longlong Fu, Fang Fang, Fang Zhou, Ying Guo, Shusong Wang, Jing Ma, Yiqun Gu, Wenhong Lu, Ying Liu   +8 more
doaj   +1 more source

Calcium signalling during human sperm interaction with cells of the female reproductive tract [PDF]

, 2012
The female reproductive tract acts not only as a complex mediator of sperm function and selection but animal data suggests that it alters protein expression after exposure to sperm, implying two-way communication.
Connolly, Thomas James
core  

NAD+ Metabolism Licenses Zygotic Genome Activation via PARP7‐Mediated ADP‐Ribosylation of UHRF1 in Mouse Early Embryos

Advanced Science, EarlyView.
This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Guangyi Cao, Ziqi Zhang, Anqi Chen, Yanbo Liu, Yuling Lin, Lina Yu, Ruixin Shi, Aolei Guo, Yan Mao, Ganggui Lou, Chaojun Li, Luhong Wen, Guijun Yan, Haixiang Sun   +13 more
wiley   +1 more source

Global status of research on fertility preservation in male patients with cancer: A bibliometric and visual analysis

Heliyon
Background: Recently, male fertility preservation before cancer treatment has become more prevalent. The research in this field has progressed over time, with some studies having a major impact and providing guidance for further research.
Chuan Huang, Xi-Ren Ji, Zeng-Hui Huang, Rui-Jun Wang, Li-Qing Fan, Wen-Bing Zhu, Qiang Luo, Qing-Li   +7 more
doaj   +1 more source

Modulation of calcium signalling in human sperm by nitric oxide [PDF]

, 2008
Nitric oxide (NO) generation by nitric oxide synthase (NOS) is implicated in gamete interaction and fertilization. In vitro studies were undertaken to assess the ability of human sperm and cumulus cells (surrounding the oocyte) to generate NO ...
Machado de Oliveira, Gisela Sofia Mendes
core  

UBE2O Drives Immune Evasion and Radioimmunotherapy Resistance in Lung Cancer by Degrading CDKL1 to Induce PD‐L1 Transcription

Advanced Science, EarlyView.
UBE2O targets CDKL1 for the degradation to upregulate PD‐L1 expression and promotes resistance to radioimmunotherapy in lung cancer, supporting the potential of targeting UBE2O as a promising therapeutic strategy. ABSTRACT Resistance to radioimmunotherapy is one of the primary causes of treatment failure in lung cancer patients; however, the underlying
Huichan Xue, Xiaohua Jie, Zhiwei Liu, Ruoxin Fang, Shuo Wu, Xiaorong Dong, Shuangbing Xu   +6 more
wiley   +1 more source

Low-Cost QCM Sensor System for Screening Semen Samples [PDF]

, 2010
Artificial insemination is a well-established part of modern agricultural practice. A viable semen sample is judged by the total number of spermatozoa (sperm) in the sample and the motility of the sperm.
Hughes, David, Carl R. Evans, Atherton, Shaun, Simon M. Stanley, Stanley, Simon, Newton, MI, Morris, Robert, Atherton, S, McHale, Glen, Evans, CR, Michael I. Newton, Newton, Michael, Evans, Carl, Morris, RH, Stanley, SM, Glen McHale, McHale, G, Robert H. Morris, Shaun Atherton, Hughes, DC, David C. Hughes   +20 more
core   +1 more source

RBM12 Maintains Glioma Stem Cells by Activating Amino Acid‐Dependent mTORC1 Signaling via SLC7A5 mRNA Stabilization

Advanced Science, EarlyView.
This study shows that in glioma stem cells (GSCs), RBM12 recruits ALKBH5 to remove m6A from SLC7A5 transcripts, thereby enhancing mRNA stability, which elevates large neutral amino acid (LNAA) levels and activates mTORC1, promoting GSC proliferation, self‐renewal, and tumor growth.
Hong Lei, Wenlong Luo, Shu Zhou, Lihao Wan, Peng Ling, Zhihua Huang, Zhihua Qian, Chenfei Lu, Mengyue Guo, Zhen Xue, Jun Qin, Ningwei Zhao, Jianghong Man, Wenchao Zhou, Zhiqiang Dong, Shutong Xu, Zhipeng Zhou, Xiuxing Wang, Weiwei Tao   +18 more
wiley   +1 more source

Design, Control, and Clinical Applications of Magnetic Actuation Systems: Challenges and Opportunities

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This review aims to provide a broad understanding for interdisciplinary researchers in engineering and clinical applications. It addresses the development and control of magnetic actuation systems (MASs) in clinical surgeries and their revolutionary effects in multiple clinical applications.
Yingxin Huo, Lidong Yang, Tiantian Xu, Dong Sun   +3 more
wiley   +1 more source