Results 81 to 90 of about 141,242 (314)
Advanced Science, EarlyView.The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Chunlin Wang +23 more
wiley +1 more source
The Ca2+-activated K+ current of human sperm is mediated by Slo3
eLife, 2014 Sperm are equipped with a unique set of ion channels that orchestrate fertilization. In mouse sperm, the principal K+ current (IKSper) is carried by the Slo3 channel, which sets the membrane potential (Vm) in a strongly pHi-dependent manner.
Christoph Brenker +10 more
doaj +1 more source
Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice
Advanced Science, EarlyView.Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li +5 more
wiley +1 more source
Angewandte Chemie, EarlyView.We present a bioluminescent diagnostic platform that integrates DNA amplification and detection in a single step. The engineering of thermostable luciferase‐intercalating dye conjugates and controlled release of caged luciferin substrates enable real‐time, detection of attomolar concentrations of viral DNA within 30 min.
Yosta de Stigter +8 more
wiley +2 more sources
Determination of a Robust Assay for Human Sperm Membrane Potential Analysis
Frontiers in Cell and Developmental Biology, 2019 Mammalian sperm must undergo a complex process called capacitation in order to fertilize the egg. During this process, hyperpolarization of the sperm plasma membrane has been mostly studied in mouse, and associated to its importance in the preparation to
Carolina Baro Graf +7 more
doaj +1 more source
Psychological and physiological adaptations to sperm competition in humans
, 2005 Postcopulatory competition between males, in the form of sperm competition, is a widespread phenomenon in many animal species. The extent to which sperm competition has been an important selective pressure during human evolution remains controversial ...
Nicholas Pound +5 more
core
Deep learning-based selection of human sperm with high DNA integrity
, 2019 Despite the importance of sperm DNA to human reproduction, currently no method exists to assess individual sperm DNA quality prior to clinical selection.
Sanner, Scott +29 more
core +1 more source
PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression
Advanced Science, EarlyView.Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian +13 more
wiley +1 more source
Endocannabinoids, sperm biology and human fertility☆
Pharmacological Research, 2009 In this review, we shall summarize the current knowledge on the endocannabinoid system (ECS), and on its involvement in the multifaceted process of male reproduction. In particular, we shall discuss the role of ECS in sperm biology and Sertoli cell proliferation and death, showing how endocannabinoids may regulate spermatogenesis and reproductive ...
Lewis S E, Maccarrone M
openaire +3 more sources
An update on the potential for male contraception : emerging options
, 2013 The human population continues to grow and is estimated to rise to 10.1 billion by the end of the century. Therefore, there is still an unmet need for safe and highly effective contraceptive options for both men and women.
Nimmo, Natalie +5 more
core +1 more source