Results 51 to 60 of about 141,242 (314)

CD4‐like molecules in human sperm [PDF]

FEBS Letters, 1990
The expression of a molecule recognized by CD4 monoclonal antibodies was investigated on human sperm using immunolabelling, biochemical and immunochemical methods. Flow cytometry detected a significant fluorescence signal. SDS‐PAGE analysis and Western blotting identified a molecule of 60 kDa, consistent with a CD4‐like structure as confirmed after ...
Gobert, Bernard, Amiel, Corinne, Tang, Jianqing, Barbarino, Patricia, Christine Béné, Marie, Faure, Gilbert   +5 more
openaire   +2 more sources

Highly conserved sperm function-related transcripts across three species: human, rat and mouse

, 2021
Assessing male reproductive toxicity of environmental and therapeutic agents relies on the histopathology of the testis and epididymis in a pre-clinical setting.
Boekelheide, Kim, Nolan, Timothy, Hwang, Kathleen, Stermer, Angela, Hall, Susan, Li, Hui, Bianchi, Enrica, Sigman, Mark   +7 more
core   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Functional remodeling of the gut microbiome and metabolome in primary idiopathic male infertility

BMC Microbiology
Background Primary idiopathic male infertility (PIMI) is a complex condition with unclear biological mechanisms. Increasing evidence indicates that gut microbiome-derived functional and metabolic alterations can influence host physiological processes ...
Chen Luo, Hailin Yao, Yang Xian, Tingting Yang, Xiao Xiao, Lijuan Ying, Jinyan Xu, Xuefeng Luo, Dajian Qiu, Yuan Liu, Bo Liu, Fuping Li   +11 more
doaj   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Integrated profiling of semen microbiota and metabolome reveals dysregulation in primary idiopathic male infertility

Journal of Translational Medicine
Background Primary idiopathic male infertility remains a significant challenge due to its complex etiology and the lack of effective diagnostic tools.
Hailin Yao, Chen Luo, Yang Xian, Bo Liu, Tingting Yang, Run Tian, Xiao Xiao, Wenrui Zhao, Lijuan Ying, Jinyan Xu, Shasha Liu, Yelin Jia, Xuefeng Luo, Dajian Qiu, Yuan Liu, Qinqin Wu, Xiaohong Luo, Zhenmi Liu, Fuping Li   +18 more
doaj   +1 more source

Non-random chromosome positioning in mammalian sperm nuclei, with migration of the sex chromosomes during late spermatogenesis.

, 2005
Chromosomes are highly organized and compartmentalized in cell nuclei. The analysis of their position is a powerful way to monitor genome organization in different cell types and states.
Foster, H, Bridger, JM, Foster, Helen A., Abeydeera, Lalantha R., Bridger, Joanna M., Griffin, DK, Abeydeera, L, Griffin, Darren K.   +7 more
core   +1 more source

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source

R-loop landscape in mature human sperm: Regulatory and evolutionary implications

Frontiers in Genetics, 2023
R-loops are three-stranded nucleic acid structures consisting of an RNA:DNA hybrid and a displaced DNA strand. While R-loops pose a potential threat to genome integrity, they constitute 5% of the human genome.
Maurice Scheuren, Jonas Möhner, Hans Zischler   +2 more
doaj   +1 more source

DNA damage in human sperm: The sperm chromosome assay

Reproductive Medicine and Biology, 2022
AbstractBackgroundSperm DNA damage is a major cause of pre‐ and post‐implantation embryonic loss in humans. However, the factors that control how and when such DNA damage occurs in human sperm are poorly understood.MethodsHere, I review information relating to sperm DNA damage that can be obtained from the sperm chromosome assays described in the ...
openaire   +3 more sources