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Drug Targets in Human T-Lymphotropic Virus Type 1 (HTLV-1) Infection

Infectious Disorders - Drug Targets, 2009
Human T-lymphotropic virus type 1 (HTLV-1), the first known human retrovirus, induces various human diseases with a long latency period. The mechanism by which the virus causes diseases is still unknown. Studies indicate that viral replication is important at least for the development of HTLV-1 associated myelopathy, and therefore treatments based on ...
Péter, Boross   +3 more
openaire   +2 more sources

Human T‐lymphotropic virus 1 (HTLV‐1) pathogenesis: A systems virology study

Journal of Cellular Biochemistry, 2018
AbstractThe main mechanisms of interaction between Human T‐lymphotropic virus type 1 (HTLV‐1) and its hosts in the manifestation of the related disease including HTLV‐1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and Adult T‐cell leukemia/lymphoma (ATLL) are yet to be determined.
Sayed‐Hamidreza Mozhgani   +11 more
openaire   +2 more sources

Detection of antibodies to human T‐lymphotropic virus type 1 (HTLV‐1)

Transfusion, 1988
Sera from 39,898 blood donors were tested for HTLV‐1 antibodies using two enzyme immunoassays (EIA). Sera testing initially reactive (IR) were retested in duplicate by both EIAs. Sera testing repeatedly reactive (RR) were further tested by two Western blots (WB) and by two radioimmunoprecipitation assays (RIPA).
C T, Fang   +4 more
openaire   +2 more sources

Human T-lymphotropic virus 1: recent knowledge about an ancient infection

The Lancet Infectious Diseases, 2007
Human T-lymphotropic virus 1 (HTLV-1) has infected human beings for thousands of years, but knowledge about the infection and its pathogenesis is only recently emerging. The virus can be transmitted from mother to child, through sexual contact, and through contaminated blood products.
Verdonck, K.   +5 more
openaire   +3 more sources

Micturitional Disturbance in Human T-Lymphotropic Virus Type-1-Associated Myelopathy

Journal of Spinal Disorders, 1994
We reported the findings of micturitional histories and urodynamic studies in five patients with human T-lymphotropic virus type-1-associated myelopathy. Histories showed that all patients had obstructive as well as irritative micturitional symptoms, and four of their micturitional symptoms appeared from the onset of the disease.
T, Hattori   +4 more
openaire   +2 more sources

Mechanisms of human T-lymphotropic virus type 1 transmission and disease

Current Opinion in Virology, 2012
Human T-lymphotrophic virus type-1 (HTLV-1) infects approximately 15-20 million people worldwide, with endemic areas in Japan, the Caribbean, and Africa. The virus is spread through contact with bodily fluids containing infected cells most often from mother to child through breast milk or via blood transfusion.
Michael D, Lairmore   +2 more
openaire   +2 more sources

Necrobiotic xanthogranuloma in a human T-lymphotropic virus type 1 carrier

Journal of the American Academy of Dermatology, 1992
A 67-year-old man who had necrobiotic xanthogranuloma associated with paraproteinemia is described. He was a human T-lymphotropic virus type 1 (HTLV-1) carrier who had a high titer of circulating anti-HTLV-1 antibodies and neurologic abnormalities that suggested HTLV-1-associated myelopathy.
M, Nishimura   +4 more
openaire   +2 more sources

Human T-Lymphotropic Virus Type 1 (HTLV-1): Persistence and Immune Control

International Journal of Hematology, 2003
The human retrovirus human T-lymphotropic virus type 1 (HTLV-1) is associated with two distinct types of disease: the malignancy known as adult T-cell leukemia and a range of chronic inflammatory conditions including the central nervous system disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).
openaire   +2 more sources

Phylogeny of human T-lymphotropic virus-1 subtypes in Guinea-Bissau

Transactions of The Royal Society of Tropical Medicine and Hygiene, 2018
Human T-cell leukaemia/lymphoma virus type 1 (HTLV-1) was the first human retrovirus discovered and there is an estimate of 15-20 million infected worldwide. Endemic areas are Japan, West Africa, Central Africa, South America, the Caribbean, Middle East, Australia and the Pacific Islands.
Kjerulff, Bertram   +6 more
openaire   +2 more sources

Human T-Lymphotropic Virus type 1 infective dermatitis in central Australia

Journal of Clinical Virology, 2013
The Human T-Lymphotropic Virus type 1 (HTLV-1) is a single-stranded RNA retrovirus that preferentially infects CD4+ T cells. The spectrum of diseases that are associated with the most frequent genotype, the HTLV-1 cosmopolitan subtype A, has been well described.
Einsiedel, Lloyd   +3 more
openaire   +3 more sources

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